{Reference Type}: Journal Article
{Title}: Circulating levels of apoptotic markers and oxidative stress parameters in women with polycystic ovary syndrome: a case-controlled descriptive study.
{Author}: Uyanikoglu H;Sabuncu T;Dursun H;Sezen H;Aksoy N;
{Journal}: Biomarkers
{Volume}: 22
{Issue}: 7
{Year}: Nov 2017
{Factor}: 2.663
{DOI}: 10.1080/1354750X.2016.1265004
{Abstract}: <B>BACKGROUND: </B>Apoptotic dysregulation plays a role in the pathogenesis of polycystic ovary syndrome (PCOS).<BR><B>OBJECTIVE: </B>To evaluate circulatory apoptotic markers and oxidative stress in patients with PCOS.<BR><B>METHODS: </B>Forty-four women with PCOS, and 44 healthy women as controls were enrolled in the study. Oxidative stress parameters and caspases levels were measured in serum.<BR><B>RESULTS: </B>The caspase 9 level was significantly lower and related with oxidant status in patients with PCOS, while the circulating levels of caspases 3 and 7 were statistically similar in both groups.<BR><B>CONCLUSIONS: </B>This study is the first report demonstrating the circulating levels of apoptotic markers and their relationship with oxidant status in PCOS.<BR><B>CONCLUSIONS: </B>The circulating caspase 9 and oxidant status might contribute to apoptotic dysregulation in PCOS.