PDF(Sci-hub)
Abstract：
Curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for its effects on human papilloma virus (HPV) infection as well as primary and malignant squamous cervical cancers. HPV infections, especially those related to HPV 16 and 18 types, have been established as the leading cause of cervical cancer; however, there are also additional contributory factors involved in the etiopathogenesis of cervical cancers. Curcumin has emerged as having promising chemopreventive and anticancer effects against both HPV-related and nonrelated cervical cancers. In this review, we first discuss the biological relevance of curcumin and both its pharmacological effects and pharmaceutical considerations from a chemical point of view. Next, the signaling pathways that are modulated by curcumin and are relevant to the elimination of HPV infection and treatment of cervical cancer are discussed. We also present counter arguments regarding the effects of curcumin on signaling pathways and molecular markers dysregulated by benzo(a)pyrene (Bap), a carcinogen found in pathological cervical lesions of women who smoke frequently, and estradiol, as two important risk factors involved in persistent HPV-infection and cervical cancer. Finally, various strategies to enhance the pharmacological activity and pharmacokinetic characteristics of curcumin are discussed with examples of studies in experimental models of cervical cancer. © 2016 BioFactors, 43(3):331-346, 2017.
摘要：
姜黄素,姜黄的生物活性多酚成分，已对其对人乳头瘤病毒（HPV）感染以及原发性和恶性鳞状宫颈癌的影响进行了广泛的研究。HPV感染,特别是与HPV16和18型有关的那些，已被确定为宫颈癌的主要原因；然而，还有其他因素参与宫颈癌的病因发生。姜黄素对HPV相关和非相关宫颈癌都具有有希望的化学预防和抗癌作用。在这次审查中,我们首先从化学角度讨论姜黄素的生物学相关性及其药理作用和药学考虑。接下来,讨论了姜黄素调节的信号通路,以及与消除HPV感染和治疗宫颈癌相关的信号通路.我们还提出了关于姜黄素对苯并（a）芘（Bap）失调的信号通路和分子标记的影响的反驳，在经常吸烟的妇女的病理性宫颈病变中发现的致癌物，和雌二醇,作为两个重要的危险因素涉及持续HPV感染和宫颈癌。最后,以宫颈癌实验模型的研究为例，讨论了增强姜黄素药理活性和药代动力学特征的各种策略。©2016BioFactors，43（3）：331-346，2017。
