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Abstract：
Lefamulin, an investigational pleuromutilin, was tested against a collection of 18 macrolide-susceptible and 42 macrolide-resistant Mycoplasma pneumoniae strains, and the results were compared with those of azithromycin, erythromycin, tetracycline, doxycycline, and moxifloxacin testing. Lefamulin was highly active against all strains tested, with all MICs at ≤0.008 μg/ml. The lefamulin MIC90 (0.002 μg/ml) for macrolide-resistant strains was the lowest among all drugs tested. Minimum bactericidal concentrations were within 2 dilutions of the MIC values, indicating a bactericidal effect.
摘要：
Lefamulin,一种研究性截短肌动素，对18个对大环内酯敏感和42个对大环内酯耐药的肺炎支原体菌株进行了测试，并将结果与阿奇霉素的结果进行了比较，红霉素,四环素,多西环素,和莫西沙星测试。Lefamulin对所有测试的菌株都具有很高的活性，所有MIC≤0.008μg/ml。大环内酯耐药菌株的lefamulinMIC90（0.002μg/ml）在所有测试药物中最低。最小杀菌浓度在MIC值的2个稀释度之内，表明有杀菌作用。
