PDF(Pubmed)
Abstract：
The putative relationship between diet, including its inflammatory potential, and breast cancer has been studied extensively, but results remain inconsistent. Using data from a large Italian case-control study conducted between 1991 and 1994, we examined the association between the dietary inflammatory index (DII) and odds of breast cancer.
DII scores were computed using a validated 78-item food frequency questionnaire. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 controls admitted to hospital for acute, non-hormone-related diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) based on continuous and quintiles of DII were estimated by multiple logistic regression adjusting for age, study center, education, BMI, parity, menopausal status, family history of hormone-related cancers, and total energy intake.
Women in quintiles 2, 3, 4 and 5 had ORs of breast cancer of 1.33 (95% CI: 1.11, 1.59), 1.37 (95% CI: 1.13, 1.66), 1.41 (95% CI: 1.15, 1.73), and 1.75 (95% CI: 1.39, 2.21), respectively, compared to women in quintile 1. One-unit increase in DII increased the odds of having breast cancer by 9% (95% CI: 1.05, 1.14).
A pro-inflammatory diet is associated to increased risk of breast cancer.
DII scores were computed using a validated 78-item food frequency questionnaire. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 controls admitted to hospital for acute, non-hormone-related diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) based on continuous and quintiles of DII were estimated by multiple logistic regression adjusting for age, study center, education, BMI, parity, menopausal status, family history of hormone-related cancers, and total energy intake.
Women in quintiles 2, 3, 4 and 5 had ORs of breast cancer of 1.33 (95% CI: 1.11, 1.59), 1.37 (95% CI: 1.13, 1.66), 1.41 (95% CI: 1.15, 1.73), and 1.75 (95% CI: 1.39, 2.21), respectively, compared to women in quintile 1. One-unit increase in DII increased the odds of having breast cancer by 9% (95% CI: 1.05, 1.14).
A pro-inflammatory diet is associated to increased risk of breast cancer.
摘要：
饮食之间的假定关系，包括它的潜在炎症，乳腺癌已经被广泛研究，但结果仍然不一致。使用1991年至1994年之间进行的大型意大利病例对照研究的数据，我们检查了饮食炎症指数（DII）与乳腺癌几率之间的关系。
使用经过验证的78项食物频率问卷计算DII分数。受试者为2569名女性，经组织学证实的乳腺癌和2588名因急性入院的对照，非激素相关疾病。基于DII的连续和五分位数的赔率比（ORs）和95％置信区间（CIs）通过调整年龄的多元逻辑回归进行估计，研究中心,教育,BMI,奇偶校验，更年期状态，激素相关癌症家族史，和总能量摄入。
第2、3、4和5个五分之一的女性乳腺癌的OR为1.33（95％CI：1.11，1.59），1.37（95%CI：1.13，1.66），1.41（95%CI：1.15，1.73），和1.75（95%CI：1.39，2.21），分别,与五分之一的女性相比。DII增加一个单位会使患乳腺癌的几率增加9％（95％CI：1.05，1.14）。
促炎饮食与乳腺癌风险增加有关。
使用经过验证的78项食物频率问卷计算DII分数。受试者为2569名女性，经组织学证实的乳腺癌和2588名因急性入院的对照，非激素相关疾病。基于DII的连续和五分位数的赔率比（ORs）和95％置信区间（CIs）通过调整年龄的多元逻辑回归进行估计，研究中心,教育,BMI,奇偶校验，更年期状态，激素相关癌症家族史，和总能量摄入。
第2、3、4和5个五分之一的女性乳腺癌的OR为1.33（95％CI：1.11，1.59），1.37（95%CI：1.13，1.66），1.41（95%CI：1.15，1.73），和1.75（95%CI：1.39，2.21），分别,与五分之一的女性相比。DII增加一个单位会使患乳腺癌的几率增加9％（95％CI：1.05，1.14）。
促炎饮食与乳腺癌风险增加有关。
