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Abstract：
BACKGROUND: Data from a nationally representative sample of 18- to 64-y-old Irish adults conducted in 1999 highlighted low phylloquinone intakes. That survey, however, did not include older adults (aged ≥65 y), a subgroup that is potentially at higher risk of low phylloquinone intakes, or a biomarker of vitamin K status.
OBJECTIVE: The objectives of this work were to measure the phylloquinone intake and its adequacy and the serum percentage of undercarboxylated osteocalcin (%ucOC), a vitamin K status biomarker, in a nationally representative sample of Irish adults aged 18-90 y, and to compare these newer data on dietary phylloquinone in adults aged 18-64 y with those from the previous survey.
METHODS: Data and biobanked serum samples from the National Adult Nutrition Survey, a randomly selected sample of Irish adults aged 18-90 y (N = 1500), were accessed. Phylloquinone intakes were estimated from 4-d food diary data and were compared across age groups (18-35, 36-50, 51-64, and ≥65 y). Serum %ucOC was assessed by immunoassay (n = 692).
RESULTS: The mean ± SD intake of phylloquinone from all sources was 85.2 ± 59.1 μg/d, 99% of which was derived from food. Phylloquinone intakes and serum %ucOC were significantly (P < 0.05) lower (14-25%) and higher (27-39%), respectively, in the 18- to 35-y age group than in the 36- to 50-y, 51- to 64-y, and ≥65-y age groups (no differences between these 3 groups; P > 0.2 in all cases). Mean phylloquinone intakes had increased (P < 0.01) modestly (6 μg/d) in 18-64-y-olds across a decade. Of the total study population, 55% had phylloquinone intakes below the United Kingdom recommended intake of 1 μg ⋅ kg body weight-1 ⋅ d-1 CONCLUSION: Our study shows that younger adults (aged 18-35 y) appear to be at higher risk of inadequate vitamin K intake and lower vitamin K status, the health implications of which are unclear and warrant further investigation.
OBJECTIVE: The objectives of this work were to measure the phylloquinone intake and its adequacy and the serum percentage of undercarboxylated osteocalcin (%ucOC), a vitamin K status biomarker, in a nationally representative sample of Irish adults aged 18-90 y, and to compare these newer data on dietary phylloquinone in adults aged 18-64 y with those from the previous survey.
METHODS: Data and biobanked serum samples from the National Adult Nutrition Survey, a randomly selected sample of Irish adults aged 18-90 y (N = 1500), were accessed. Phylloquinone intakes were estimated from 4-d food diary data and were compared across age groups (18-35, 36-50, 51-64, and ≥65 y). Serum %ucOC was assessed by immunoassay (n = 692).
RESULTS: The mean ± SD intake of phylloquinone from all sources was 85.2 ± 59.1 μg/d, 99% of which was derived from food. Phylloquinone intakes and serum %ucOC were significantly (P < 0.05) lower (14-25%) and higher (27-39%), respectively, in the 18- to 35-y age group than in the 36- to 50-y, 51- to 64-y, and ≥65-y age groups (no differences between these 3 groups; P > 0.2 in all cases). Mean phylloquinone intakes had increased (P < 0.01) modestly (6 μg/d) in 18-64-y-olds across a decade. Of the total study population, 55% had phylloquinone intakes below the United Kingdom recommended intake of 1 μg ⋅ kg body weight-1 ⋅ d-1 CONCLUSION: Our study shows that younger adults (aged 18-35 y) appear to be at higher risk of inadequate vitamin K intake and lower vitamin K status, the health implications of which are unclear and warrant further investigation.
摘要：
背景：1999年进行的18至64岁爱尔兰成年人的全国代表性样本数据突出显示了低叶醌摄入量。这项调查,然而,不包括老年人(年龄≥65岁)，一个亚组，有可能在低的苯醌摄入量的风险较高，或维生素K状态的生物标志物。
目的：这项工作的目的是测量苯醌的摄入量及其充足性和低羧化骨钙蛋白（％ucOC）的血清百分比，维生素K状态生物标志物，在18-90岁的爱尔兰成年人的全国代表性样本中，并将这些关于18-64岁成年人膳食苯醌的新数据与之前调查的数据进行比较。
方法：来自全国成人营养调查的数据和生物样本，随机抽取18-90岁的爱尔兰成年人样本(N=1500)，被访问。根据4天的食物日记数据估算了Phylloquinum的摄入量，并在各年龄组（18-35、36-50、51-64和≥65岁）进行了比较。通过免疫测定评估血清%ucOC(n=692)。
结果：所有来源的苯醌的平均±SD摄入量为85.2±59.1μg/d，其中99%来自食物。叶醌摄入量和血清％ucOC显着（P<0.05）降低（14-25％）和升高（27-39％），分别,在18至35岁年龄组比在36至50岁年龄组，51-到64-y，和≥65岁年龄组（这3组间无差异；所有病例P>0.2）。在过去的十年中，18-64岁的人的平均苯醌摄入量略有增加（P<0.01）（6μg/d）。在整个研究人群中,55％的苯醌摄入量低于英国推荐的摄入量1μg·kg体重-1·d-1。结论：我们的研究表明，年轻的成年人（18-35岁）似乎有更高的维生素K摄入不足的风险和较低的维生素K状态，其对健康的影响尚不清楚，需要进一步调查。
目的：这项工作的目的是测量苯醌的摄入量及其充足性和低羧化骨钙蛋白（％ucOC）的血清百分比，
方法：来自全国成人营养调查的数据和生物样本，
结果：所有来源的苯醌的平均±SD摄入量为85.2±59.1μg/d，
