诊断时检测到的双等位基因 ATM 改变可识别出治疗初期的慢性淋巴细胞白血病患者的一部分 , 其总体生存率降低 , 与 p53 缺失患者相似。
关键词: 11q deletion ATM mutation chronic lymphocytic leukemia p53 deletion prognostic markers
Mesh : Aged Aged, 80 and over Alleles Ataxia Telangiectasia Mutated Proteins / genetics Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 17 DNA Mutational Analysis Female Gene Deletion Gene Frequency Humans Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis drug therapy genetics mortality Male Middle Aged Mutation Prognosis Proportional Hazards Models Tumor Suppressor Protein p53
来 源:
DOI:10.1080/10428194.2016.1213829
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