关键词: A-seco-rearranged cassane Anti-inflammation activity Caesalpinia Caesalpinia minax Hance Circular dichroism Conformation analysis

Mesh : Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry pharmacology Caesalpinia / chemistry Cell Line / drug effects Crystallography, X-Ray Diterpenes / chemistry pharmacology Drug Evaluation, Preclinical / methods Drugs, Chinese Herbal / chemistry Furans / chemistry pharmacology Lipopolysaccharides / pharmacology Mice Molecular Structure Nitric Oxide / metabolism Seeds / chemistry

来  源:   DOI:10.1016/j.phytochem.2015.06.025   PDF(Sci-hub)

Abstract:
Cassane skeletons are rare in nature, but often possess valuable medicinal properties. A furanoditerpenoid with an unusual A-seco-rearranged cassane skeleton, neocaesalminin A, and five furanoditerpenoids were isolated from seeds of Caesalpinia minax Hance, along with six known cassane derivatives, 7-O-acetyl-bonducellpin C, caesalmin F, caesalmin C, ζ-caesalmin, caesalmin E1 and caesalpinin K. Compound structures were determined by spectroscopy (HR-ESI-MS, UV, IR, 1D NMR, 2D NMR), X-ray crystallography and quantum chemical computation of electronic circular dichroism). Three of the previously known compounds exhibited significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).
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