%0 Journal Article
%T Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance.
%A Dong R
%A Yuan J
%A Wu S
%A Huang J
%A Xu X
%A Wu Z
%A Gao H
%J Phytochemistry
%V 117
%N 0
%D Sep 2015
%M 26125942
%F 4.004
%R 10.1016/j.phytochem.2015.06.025
%X Cassane skeletons are rare in nature, but often possess valuable medicinal properties. A furanoditerpenoid with an unusual A-seco-rearranged cassane skeleton, neocaesalminin A, and five furanoditerpenoids were isolated from seeds of Caesalpinia minax Hance, along with six known cassane derivatives, 7-O-acetyl-bonducellpin C, caesalmin F, caesalmin C, ζ-caesalmin, caesalmin E1 and caesalpinin K. Compound structures were determined by spectroscopy (HR-ESI-MS, UV, IR, 1D NMR, 2D NMR), X-ray crystallography and quantum chemical computation of electronic circular dichroism). Three of the previously known compounds exhibited significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).