PDF(Pubmed)
Abstract：
Pregnancy and birth cohorts have been utilised extensively to investigate the developmental origins of health and disease, particularly in relation to understanding the aetiology of obesity and related cardiometabolic disorders. Birth and pregnancy cohorts have been utilised extensively to investigate this area of research. The aim of the present review was twofold: first to outline the necessity of measuring cardiometabolic risk in children; and second to outline how it can be assessed. The major outcomes thought to have an important developmental component are CVD, insulin resistance and related metabolic outcomes. Conditions such as the metabolic syndrome, type 2 diabetes and CHD all tend to have peak prevalence in middle-aged and older individuals but assessments of cardiometabolic risk in childhood and adolescence are important to define early causal factors and characterise preventive measures. Typically, researchers investigating prospective cohort studies have relied on the thesis that cardiovascular risk factors, such as dyslipidaemia, hypertension and obesity, track from childhood into adult life. The present review summarises some of the evidence that these factors, when measured in childhood, may be of value in assessing the risk of adult cardiometabolic disease, and as such proceeds to describe some of the methods for assessing cardiometabolic risk in children.
摘要：
怀孕和出生队列已被广泛用于调查健康和疾病的发育起源，特别是在了解肥胖和相关心脏代谢紊乱的病因方面。出生和怀孕队列已被广泛用于调查这一研究领域。本综述的目的是双重的：首先概述测量儿童心脏代谢风险的必要性；其次概述如何评估。被认为具有重要发育成分的主要结果是CVD，胰岛素抵抗和相关代谢结果。比如代谢综合征，2型糖尿病和CHD在中年和老年个体中的患病率均达到高峰,但评估儿童和青少年时期的心脏代谢风险对于确定早期致病因素和确定预防措施的特征非常重要.通常,调查前瞻性队列研究的研究人员依赖于心血管危险因素，比如血脂异常,高血压和肥胖，从童年到成人生活。本综述总结了这些因素的一些证据，当在童年测量时，可能对评估成人心脏代谢疾病的风险有价值，因此，继续描述一些评估儿童心脏代谢风险的方法。
