关键词: CK-1827452 NONMEM cardiac myosin activator inotrope omecamtiv mecarbil population PK-PD stable heart failure systolic ejection time
Mesh : Adult Aged Cardiac Myosins / metabolism Cross-Over Studies Double-Blind Method Female Healthy Volunteers Heart Failure / metabolism physiopathology Humans Male Middle Aged Models, Biological Stroke Volume / drug effects Systole / drug effects Urea / analogs & derivatives blood pharmacokinetics pharmacology Young Adult
来 源:
DOI:10.1002/jcph.538
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