关键词: SLC25A4 TSPO adenine nucleotide translocator antipsychotic genetics mitochondria peripheral benzodiazepine receptor pharmacogenomics schizophrenia translocator protein-18 kDa weight gain

Mesh : Adolescent Adult Antipsychotic Agents / administration & dosage adverse effects Female Genetic Association Studies Humans Male Middle Aged Receptors, GABA / genetics Schizophrenia / drug therapy genetics pathology Treatment Outcome Weight Gain / genetics

来  源:   DOI:10.2217/pgs.14.158   PDF(Sci-hub)

Abstract:
OBJECTIVE: TSPO is a neuroinflammatory biomarker and emerging therapeutic target in psychiatric disorders. We evaluated whether TSPO polymorphisms contribute to interindividual variability in schizophrenia, antipsychotic efficacy and antipsychotic-induced weight gain.
METHODS: We analyzed TSPO polymorphisms in 670 schizophrenia cases and 775 healthy controls. Gene-gene interactions between TSPO and other mitochondrial membrane protein-encoding genes (VDAC1 and ANT1) were explored. Positive findings were evaluated in two independent samples (Munich, n = 300; RUPP, n = 119).
RESULTS: TSPO rs6971 was independently associated with antipsychotic-induced weight gain in the discovery (puncor = 0.04) and RUPP samples (p = 3.00 × 10(-3)), and interacted with ANT1 rs10024068 in the discovery (p = 1.15 × 10(-3)) and RUPP samples (p = 2.76 × 10(-4)).
CONCLUSIONS: Our findings highlight TSPO as a candidate for future investigations of antipsychotic-induced weight gain, and support the involvement of mitochondrial membrane components in this serious treatment side effect.
摘要:
暂无翻译
公众号