■药物基因组学(PGx)是基因如何影响药物反应的公认概念,许多研究表明药物副作用的减少,提高疗效和成本效益。尽管有这些好处,PGx在日常实践中的实施仍然有限。在临床实践中实施PGx的研究以前发现,知识不足是主要障碍之一。有关家庭医学临床医生中具体存在哪些教育需求的详细信息需要进一步研究。
■这项研究的目的是确定药物基因组学(PGx)在初级保健实践中可以发挥的感知作用,家庭医学临床医生经历的知识差距,以及他们在日常练习中使用PGx所需的技能。
■为了实现这一目标,态度,知识,障碍,需要的技能,通过半结构化访谈和知识测验,在家庭医学临床医生焦点小组研究中探索了首选的教育计划。第二,多学科焦点小组提供了有关在患者护理中使用PGx的知识水平和必要技能的信息。从两个焦点小组收集关键记录信息后,药物基因组学可能在初级保健中发挥的作用,主要的知识差距,通过定性分析确定了最合适的教育方案。
■出现了关于PGx教育需求和PGx在家庭医学中的作用的四个主题:1)对PGx能力的需求,2)深入了解PGx服务的角色和职责,3)通过集成在电子健康档案中的人工智能优化PGx工作流程,4)与PGx相关的伦理困境和心理效应。这些主题反映了PGx在家庭医学中的作用发生了变化,对教育产生了影响。
■从这项研究中获得的结果将有助于改善PGx在日常实践中的实施,因此,可能导致PGx的利用率增加,从而导致改善的药物疗效和减少的副作用。
UNASSIGNED: Pharmacogenomics (PGx) is a well-established concept of how genes impact medication response, with many studies demonstrating reductions in medication side effects, improved efficacy and cost effectiveness. Despite these benefits, implementation of PGx in daily practice remains limited. Studies on the implementation of PGx in clinical practice have previously found that inadequate knowledge is one of the main barriers. Details regarding specifically which educational needs exist among family medicine clinicians requires further study.
UNASSIGNED: The aim of this study was to identify both the perceived role that
pharmacogenomics (PGx) could play in primary care practice, the knowledge gaps that family medicine clinicians experience, and the skills they require to use PGx in their daily practice.
UNASSIGNED: To achieve this aim, the attitudes, knowledge, barriers, skills needed, and preferred educational program were explored in a family medicine clinician focus group study via a semi-structured interview and knowledge quiz. Second, multidisciplinary focus groups provided information on the level of knowledge and necessary skills to use PGx in patient care. After gathering key recorded information from both focus groups, the perceived role
pharmacogenomics could possibly play in primary care, the predominant knowledge gaps, and the most appropriate educational program was determined by qualitative analysis.
UNASSIGNED: Four themes emerged regarding the PGx educational needs and the role of PGx in family medicine: 1) need for PGx competences, 2) insight into the roles and responsibilities of PGx services, 3) optimization of PGx workflow through artificial intelligence integrated in the electronic health record, and 4) the ethical dilemmas and psychological effects related to PGx. These themes reflect a shift in the role of PGx in family medicine with implications for education.
UNASSIGNED: The results obtained from this study will help improve the implementation of PGx in daily practice, and consequently, may result in increased utilization of PGx, thereby resulting in improved medication efficacy and reduced side effects.