p21Cip1 / CDKN1A 的缺失使得癌细胞对 Polo 样激酶 1 抑制敏感。
关键词: DNA damage Plk1 inhibitors apoptosis p21 senescence
Mesh : Antineoplastic Agents / pharmacology Apoptosis / drug effects Benzoates / pharmacology Cell Cycle Checkpoints / drug effects Cell Cycle Proteins / antagonists & inhibitors metabolism Cell Survival / drug effects Cellular Senescence / drug effects Colonic Neoplasms / drug therapy enzymology genetics pathology Cyclin-Dependent Kinase Inhibitor p21 / deficiency genetics DNA Damage Dose-Response Relationship, Drug Down-Regulation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HCT116 Cells Humans Inhibitory Concentration 50 Molecular Targeted Therapy Protein Kinase Inhibitors / pharmacology Protein Serine-Threonine Kinases / antagonists & inhibitors metabolism Proto-Oncogene Proteins / antagonists & inhibitors metabolism Quinones / pharmacology RNA Interference Signal Transduction / drug effects Time Factors Transfection Polo-Like Kinase 1
来 源:
DOI:10.18632/oncotarget.2844
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