miR - 499 通过其对 Pdcd4 和 Pacs2 的作用保护心肌细胞免受 H 2O 2 诱导的凋亡。
关键词: BID PACS2 PDCD4 c-Jun miR-499 mitochondrial apoptosis pathway
Mesh : Animals Animals, Newborn Apoptosis / drug effects genetics Apoptosis Regulatory Proteins / genetics BH3 Interacting Domain Death Agonist Protein / genetics metabolism Gene Expression Profiling Gene Expression Regulation Hydrogen Peroxide / pharmacology Male MicroRNAs / genetics Myocytes, Cardiac / drug effects metabolism Phosphorylation Protein Serine-Threonine Kinases / genetics Protein-Tyrosine Kinases / genetics Proto-Oncogene Proteins c-jun / metabolism RNA Interference RNA, Messenger Rats Reactive Oxygen Species Vesicular Transport Proteins / genetics Dyrk Kinases
来 源:
DOI:10.4161/rna.28300
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