关键词: biphasic insulin secretion lixisenatide minimal model perfused pancreas β-cell function
Mesh : Algorithms Animals Glucagon-Like Peptide 1 / agonists metabolism pharmacology Glucagon-Like Peptide-1 Receptor Glucose / metabolism Hypoglycemic Agents / agonists metabolism pharmacology In Vitro Techniques Insulin / metabolism Insulin Secretion Insulin-Secreting Cells / drug effects metabolism Kinetics Male Models, Biological Monomeric GTP-Binding Proteins / metabolism pharmacology Pancreas / drug effects metabolism Peptides / pharmacology Perfusion Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled / agonists metabolism Receptors, Glucagon / agonists metabolism Reproducibility of Results Signal Transduction / drug effects
来 源:
DOI:10.1152/ajpendo.00603.2013
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