肝脏整体基因表达谱在致癌物呋喃风险评估中的应用案例研究。
关键词: AP-1 APAP ASK1 Acetaminophen Activator protein 1 Apoptosis signaling kinase BDA BMD BMDL Benchmark dose Body weight BrdU Bromodeoxyuridine CT Carbon tetrachloride Cyp2E1 Cytochrome P450 2E1 ERK EtOH Ethanol Extracellular signal-regulated kinase Furan GO GSH Gene expression Gene ontology Glutathione HCA HCC Hepatocellular adenoma Hepatocellular carcinoma IARC IPA IRIS Indirect-acting genotoxic carcinogen Ingenuity Pathway Analysis Integrated Risk Information System International Agency for Research on Cancer JNK1 Jun proto-oncogene Lower confidence limit of benchmark dose MAPK MOA MPT Mitochondrial permeability transition Mitogen-activated protein kinase Mode of action NF-κB NTP National Toxicology Program Non-genotoxic carcinogen Nrf2/NFE2L2 Nuclear factor (erythroid-derived 2)-like 2 Nuclear factor kappa B PH POD Partial hepatectomy Point of departure ROS Reactive oxygen species Risk assessment SAPK Stress-activated protein kinase TNF TNF receptor 1 TNFR1 Toxicogenomics Tumor necrosis factor bw c-Jun c-Jun NH2-terminal kinase 1 cis-2-butene-1,4-dial
Mesh : Animals Carcinogens / toxicity Dose-Response Relationship, Drug Female Furans / toxicity Gene Expression Profiling / methods Hepatocytes / drug effects metabolism Liver / drug effects metabolism Mice Risk Assessment
来 源: DOI:10.1016/j.taap.2013.10.019