关键词: A AUC Adenine Afr Africans As Asians C C(t) Cauc./Cau Caucasians Cl Cl(Het) Cl(Hom) Cl(Wt) Clearance Clearance of the heterozygous alleles Clearance of the homozygous alleles Clearance of the wild-type alleles Cyclosporine Cytosine Drug metabolism E(Het) E(Hom) E(Wt) G Guanine HIV Het Heterozygous Hom Homozygous MD NSAID(s) PK PharmGKB Pharmacogenetics Pharmacogenetics-based dose adjustments Pharmacogenomics Knowledgebase Polymorphism Reference SD SN-38 Sign Significant Sirolimus T Tacrolimus Thymine UDP UDP-glucuronosyltransferase UDP-glucuronosyltransferases UGT UGT1A1 Wt area under the curve cyc genotype effects of the heterozygous alleles genotype effects of the homozygous alleles genotype effects of the wild-type alleles human immunodeficiency virus infection i.e. id est (that is) metabolite of Irinotecan multiple dose non-steroidal antiinflammatory drugs pharmacokinetics ref./Ref single dose sir tac trough concentration uridine diphosphate wild type
Mesh : Analgesics / metabolism pharmacokinetics Anti-HIV Agents / metabolism pharmacokinetics Antihypertensive Agents / metabolism pharmacokinetics Antineoplastic Agents / metabolism pharmacokinetics Glucuronosyltransferase / genetics metabolism Humans Pharmaceutical Preparations / administration & dosage metabolism Pharmacokinetics Polymorphism, Genetic Psychotropic Drugs / metabolism pharmacokinetics Uridine Diphosphate / metabolism
来 源: DOI:10.1016/j.pharmthera.2013.09.002