跑台运动对应激大鼠海马 BDNF 介导通路的影响。
关键词: 5-HT BDNF Brain-derived neurotrophic factor CREB ERK FST G-protein coupled receptor GPCR GSK-3β Glycogen synthase kinase-3β HPA Immobilization stress MAPK MTOR N-Methyl-d-aspartate NE NLG 1 NMDA PI3K PKA PSD-95 Phosphatidylinositol 3-kinase SYP Synaptic proteins Treadmill exercise cAMP response element binding protein extracellular signal-regulated kinase forced-swimming test hypothalamus–pituitary–adrenal mTOR mammalian target of rapamycin mitogen-activated protein kinase neuroligin 1 norepinephrine p70 ribosomal protein S6 kinase p70S6K postsynaptic density protein-95 protein kinase A serotonin synaptophysin
Mesh : Animals Brain-Derived Neurotrophic Factor / metabolism Glycogen Synthase Kinase 3 / metabolism Glycogen Synthase Kinase 3 beta Hippocampus / metabolism Male Neuronal Plasticity / physiology Neurons / metabolism Physical Conditioning, Animal / methods Proto-Oncogene Proteins c-akt / metabolism Rats Rats, Sprague-Dawley Signal Transduction / physiology Stress, Physiological Synapses / metabolism
来 源:
DOI:10.1016/j.neures.2013.04.005
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