p21 激活的激酶 1 (PAK1) 可以非激酶依赖性的方式促进 ERK 的激活。
关键词: ERK MAP Kinases (MAPKs) MEK PAK RAF Rac1 Scaffold Proteins
Mesh : Animals Enzyme Activation / physiology HEK293 Cells HeLa Cells Humans MAP Kinase Kinase 1 / genetics metabolism MAP Kinase Kinase 2 / genetics metabolism MAP Kinase Signaling System / physiology Mice NIH 3T3 Cells Neuropeptides / genetics metabolism Phosphorylation / physiology Proto-Oncogene Proteins B-raf / genetics metabolism Proto-Oncogene Proteins c-raf / genetics metabolism p21-Activated Kinases / genetics metabolism rac GTP-Binding Proteins / genetics metabolism rac1 GTP-Binding Protein / genetics metabolism
来 源:
DOI:10.1074/jbc.M112.426023
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