关键词: 3Rs BWL Body weight loss (BWL) Dogs MTD Maximum tolerated dose (MTD) NC3Rs NHPs National centre for the replacement, refinement and reduction of animals in research Non-human primates (NHPs) Preclinical Rats Refinement Regulatory toxicology Short term toxicity study body weight loss maximum tolerated dose non-human primates replacement, reduction, refinement
Mesh : Animals Body Weight / drug effects Dogs Drug Industry / methods Drug-Related Side Effects and Adverse Reactions Humans Maximum Tolerated Dose Primates Rats Toxicity Tests, Acute / methods Weight Loss / drug effects
来 源:
DOI:10.1016/j.yrtph.2013.04.003
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