Mesh : Amino Acid Sequence Amino Acid Substitution Antifungal Agents / administration & dosage Aspergillosis / drug therapy microbiology Aspergillus fumigatus / drug effects enzymology genetics Cytochrome P-450 Enzyme System / genetics metabolism Drug Resistance, Fungal / drug effects genetics Female Fungal Proteins / genetics metabolism Genotype Humans Itraconazole / administration & dosage Microbial Sensitivity Tests Middle Aged Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Mutation Rate Phenotype Polymorphism, Single Nucleotide Sputum / microbiology Time Factors Triazoles / administration & dosage
来 源:
DOI:10.1128/AAC.05088-11
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