Abstract：
A 19-year-old Japanese man had been treated for ulcerative colitis for 2 years. He was admitted to our hospital with nodulocystic inflammatory papules and pustules on his face and chest, high-grade fever, arthralgia and general malaise. A biopsy specimen from a pustule showed prominent infiltration of neutrophils in the epidermis and dermis, particularly around hair follicles. We made a diagnosis of acne fulminans. The systemic administration of prednisolone at 30 mg daily for 1 week immediately improved his skin lesions and other symptoms; however, during tapering of prednisolone at 20 mg daily, skin lesions flared up. The addition of oral diaminodiphenylsulfone improved the skin lesions. Although there have been a few reports of acne fulminans associated with Crohn\'s disease, this is the first case report of acne fulminans in a patient with ulcerative colitis. It is noteworthy that the addition of diaminodiphenylsulfone was effective for treating the relapse of acne fulminans in this case.
摘要：
一名19岁的日本男子因溃疡性结肠炎接受了2年的治疗。他因面部和胸部有结节囊性炎性丘疹和脓疱入院，高烧,关节痛和全身不适。脓疱的活检标本显示表皮和真皮中嗜中性粒细胞明显浸润，特别是毛囊周围。我们对暴发性痤疮进行了诊断。全身给药泼尼松龙30mg每天1周立即改善他的皮肤损伤和其他症状;然而，在每天20毫克的泼尼松龙逐渐减少期间，皮肤损伤突然发作.口服二氨基二苯砜的加入改善了皮肤损伤。虽然有一些报道称痤疮暴发性与克罗恩病有关，这是一例溃疡性结肠炎患者的痤疮暴发性病例报告。值得注意的是,在这种情况下,添加二氨基二苯砜对于治疗暴发性痤疮的复发是有效的。
