基因组数据在风险评估案例研究中的使用 : I. 邻苯二甲酸二丁酯男性生殖发育毒性数据集的评估。
关键词: AGD BMDL DBP Dibutyl phthalate GD IRIS Integrated Risk Information System LOAEL LOEL MOA NOAEL NOEL NRC NTP National Research Council National Toxicology Program OECD Organisation of Economic Co-operation and Development PND POD RACB RT-PCR RfD Risk assessment T Toxicogenomic U.S. EPA U.S. Environmental Protection Agency WOE anogenital distance benchmark dose lower confidence limit dibutyl phthalate gestation day lowest-observed-adverse-effect level lowest-observed-effect level mode of action no-observed-adverse-effect level no-observed-effect level point of departure postnatal day reference dose reproductive assessment by continuous breeding reverse transcriptase polymerase chain reaction testosterone weight of evidence
Mesh : Animals Dibutyl Phthalate / toxicity Environmental Pollutants / toxicity Genitalia, Male / drug effects growth & development pathology Genomics Male Plasticizers / toxicity Rats Reproduction / drug effects Risk Assessment
来 源:
DOI:10.1016/j.taap.2010.09.006
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