Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples.

• 影响指数: 11.225
• 发表时间: Jan 2010 30
• 来源期刊: Psychiatry Res
• DOI: 10.1016/j.psychres.2009.08.005
• PMID: 19892407
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Hirata Y,Souza RP,Lieberman JA,Meltzer HY,Kennedy JL

Mesh: Adult; Case-Control Studies; Chi-Square Distribution; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study / methods; Genotype; Humans; Male; Polymorphism, Genetic / genetics; Receptors, Serotonin, 5-HT4 / genetics; Schizophrenia / genetics

Abstract

Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.