Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting.

• 影响指数: 5.335
• 发表时间: Jan 2008
• 来源期刊: Pathology
• DOI: 10.1080/00313020701717720
• PMID: 18038317
• 文章类型: Consensus Development Conference
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Wong RC,Favaloro EJ,Adelstein S,Baumgart K,Bird R,Brighton TA,Empson M,Gillis D,Hendle MJ,Laurent R,Mallon D,Pollock W,Smith S,Steele RH,Wilson RJ

Mesh: Antibodies, Anti-Idiotypic / blood immunology; Antiphospholipid Syndrome / blood diagnosis immunology; Australasia; Cardiolipins / immunology; Clinical Laboratory Techniques; Humans; Sensitivity and Specificity; beta 2-Glycoprotein I / immunology

Abstract

Consensus guidelines on anti-beta 2 glycoprotein I (anti-beta2GPI) testing have been developed to help minimise laboratory variation in the performance and reporting of assays for these antibodies. These guidelines include minimum and optional recommendations for the following aspects of anti-beta2GPI testing and reporting: (1) isotype of anti-beta2GPI tested; (2) specimen type; (3) controls and assay precision; (4) calibrators; (5) patient samples; (6) rheumatoid factors and IgM anti-beta2GPI testing; (7) reporting of results; (8) cutoff values; and (9) interpretative comments. Issues related to inter-kit/assay standardisation and the manufacturing process of commercial anti-beta2GPI kits/assays have not been addressed in the current guidelines.