Mesh : Animals Benzimidazoles / pharmacology Cell Line Computer Simulation Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System / analysis genetics isolation & purification metabolism Diphosphonates / pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical Female Genes, Reporter Hepatocytes / drug effects metabolism Humans Ligands Luciferases / metabolism Luminescent Measurements Mice Mice, Nude Models, Molecular Neoplasm Transplantation Pregnane X Receptor RNA, Messenger / metabolism Receptors, Steroid / agonists metabolism Structure-Activity Relationship Sulfonamides / pharmacology
来 源:
DOI:10.1124/mol.106.033415
PDF(Sci-hub)