METHODS: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies.
RESULTS: There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia.
CONCLUSIONS: In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.
方法:SIGMAR1基因两个多态性之间的病例对照关联研究,G-241T/C-240T和Gln2Pro,和精神分裂症在日本人群中,和荟萃分析,包括目前和以前的研究。
结果:多态性的任何等位基因或基因型与精神分裂症均无显著关联。与精神分裂症的hebeprenic或偏执亚型均未观察到显着关联。此外,一项荟萃分析,包括本研究和以前的研究,包括779名对照和636名精神分裂症患者,也显示SIGMAR1基因与精神分裂症之间没有显著关联.
结论:鉴于这一证据,SIGMAR1基因可能不赋予精神分裂症易感性.