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Abstract：
In recent years the physiological role of the proinsulin C-peptide has received increasing attention, focusing on the potential therapeutic value of C-peptide replacement in preventing and ameliorating type 1 diabetic complications. In order to consolidate these new data and to identify the immediate directions of C-peptide research and its clinical usefulness, an International Symposium was held in Detroit, Michigan, on October 20-21, 2000, under the auspices of the Wayne State University/Morris Hood Jr. Comprehensive Diabetes Center. In this communication, we review the cellular, physiological and clinical effects of C-peptide replacement in animal models and in patients with type 1 diabetes. Finally, recommendations are presented as to the most urgent studies that should be pursued to further establish the biological action of C-peptide and its therapeutic value.
摘要：
近年来,胰岛素原C肽的生理作用日益受到重视,重点关注C肽替代治疗在预防和改善1型糖尿病并发症中的潜在治疗价值。为了巩固这些新数据并确定C肽研究的直接方向及其临床实用性，在底特律举行了一次国际研讨会，密歇根州,2000年10月20日至21日，在韦恩州立大学/莫里斯·胡德综合糖尿病中心的主持下。在这份通讯中,我们检查细胞，C肽替代在动物模型和1型糖尿病患者中的生理和临床作用。最后,提出了关于应进行的最紧迫研究的建议，以进一步确定C肽的生物学作用及其治疗价值。
