%0 Consensus Development Conference
%T Proinsulin C-peptide--a consensus statement.
%A Sima AA
%A Grunberger G
%A Jörnvall H
%A Wahren J
%A  
%J Int J Exp Diabetes Res
%V 2
%N 2
%D 2001
%M 12369718
暂无%R 10.1155/edr.2001.145
%X In recent years the physiological role of the proinsulin C-peptide has received increasing attention, focusing on the potential therapeutic value of C-peptide replacement in preventing and ameliorating type 1 diabetic complications. In order to consolidate these new data and to identify the immediate directions of C-peptide research and its clinical usefulness, an International Symposium was held in Detroit, Michigan, on October 20-21, 2000, under the auspices of the Wayne State University/Morris Hood Jr. Comprehensive Diabetes Center. In this communication, we review the cellular, physiological and clinical effects of C-peptide replacement in animal models and in patients with type 1 diabetes. Finally, recommendations are presented as to the most urgent studies that should be pursued to further establish the biological action of C-peptide and its therapeutic value.