Abstract：
Irregular menstrual bleeding, the most common side effect of Depo-Provera use, is being managed by some physicians through administration of estrogen and/or ibuprofen. A practitioner from the Jones Institute for Reproductive Medicine in Norfolk, Virginia, reported that women with 8-10 days of bleeding over 2 weeks are administered 0.02 mg of ethinyl estradiol for 10 days; bleeding generally stops in 5 days. Other physicians prescribe an estrogen patch. If estrogen is contraindicated, patients are given 800 mg of ibuprofen 3 times a day for 5 days. In all cases of heavy bleeding apparently related to Depo-Provera use, other causes (e.g., cervical malignancy, uterine fibroids, sexually transmitted diseases) should be ruled out before treatment is initiated. Finally, several clinicians noted that counseling Depo-Provera acceptors to anticipate irregular bleeding for as long as a year is perhaps the most effective management strategy.
摘要：
不规则的月经出血，使用Depo-Provera最常见的副作用，由一些医生通过雌激素和/或布洛芬的管理。诺福克琼斯生殖医学研究所的医生，弗吉尼亚,据报道，在2周内有8-10天出血的妇女，服用0.02mg乙炔雌二醇10天；出血通常在5天内停止。其他医生开了一个雌激素贴片。如果雌激素是禁忌的，患者给予布洛芬800毫克，每天3次，共5天。在所有明显与使用Depo-Provera有关的大量出血病例中，其他原因(例如，宫颈恶性肿瘤,子宫肌瘤,性传播疾病)应在开始治疗前排除。最后,一些临床医生指出,咨询Depo-Provera受体,预测不规则出血长达一年可能是最有效的治疗策略.
