本研究旨在探讨角膜生物力学特性的影响,角膜滞后(CH),角膜阻力因子(CRF)对白内障术后散光的影响及其他因素的影响。40例患者的40只眼(13M/27F;中位年龄74岁)纳入本前瞻性研究,接受2.75mm切口白内障手术,并被跟踪了30天。在手术前的基线(V0)安排访视,第一(V1),第七(V2)术后第30天(V3)。用Statistica®14.0.1估计和分析的主要参数是CH,CRF,散光屈光度,和轴。白内障手术后,研究访视期间CH无显著变化(p=0.109).然而,在研究访视期间(根据方案组),CRF与基线相比有显著变化(p=0.002).在从V0到V1轻微但不显著的增加之后,事后分析发现平均CRF从V1到V2显著降低(p=0.049),从V2到V3没有实质性变化。根据事后分析,中位散光屈光度从V0到V1仅显著增加(p=0.001),并且在研究结束时略有降低,但没有显著降低,达到接近基线值.通过逐步回归分析获得的最终散光屈光度(R2=0.898)的主要预测因子是其在V0,V1和V2的值(p<0.001)。V1时的CRF略有差异,负参数估计为-0.098303(p=0.0623)。总之,使用2.75mm切口白内障手术,术前CH和CRF与术后散光之间没有相关性。然而,最终散光屈光度的主要预测指标是白内障手术前的基线值,第一,和术后第七天。
This study aimed to investigate the impact of the cornea\'s biomechanical properties, corneal hysteresis (CH), and corneal resistance factor (CRF) on postoperative astigmatism after
cataract surgery and determine the other factors that influence it. Forty eyes of 40 patients (13M/27F; the median age of 74) were included in this prospective study, underwent 2.75 mm incision
cataract surgery, and were followed for 30 days. Visits were scheduled at baseline before surgery (V0), the 1st (V1), the 7th (V2), and the 30th (V3) postoperative days. The main parameters estimated and analyzed with Statistica® 14.0.1 were CH, CRF, astigmatism diopter, and axis. Following the
cataract surgery, the CH did not significantly change during the study visits (p = 0.109). However, there was a significant change in the CRF from baseline during the study visits (per protocol set) (p = 0.002). After a slight but insignificant increase from V0 to V1, post hoc analysis found a significant decrease in the mean CRF from V1 to V2 (p = 0.049) with no substantial change from V2 to V3. According to the post hoc analysis, the median astigmatism diopter increased significantly only from V0 to V1 (p = 0.001) and slightly but not significantly decreased to the end of the study with the achievement of a near-baseline value. The main predictors for the final astigmatism diopter (R2 = 0.898) obtained by stepwise regression analysis were its values at V0, V1, and V2 (p < 0.001). The CRF at V1 was marginally significant, with a negative parameter estimate of -0.098303 (p = 0.0623). In conclusion, there was no correlation between preoperative CH and CRF and postoperative astigmatism using 2.75 mm incision
cataract surgery. However, the final astigmatism diopter\'s main predictors were its baseline values before
cataract surgery, the first, and the seventh postoperative days.