■镉,一种有毒的重金属,由于镍镉电池的兴起,在20世纪经历了产量的激增,金属电镀,和塑料稳定剂。接触镉主要是通过食用受污染的食物,比如蔬菜和谷物,以及饮用水或吸入污染空气。本研究的目的是使用系统评价和荟萃分析方法研究镉暴露与前列腺癌发病率之间的关系。
■这项研究涉及从各种数据库中搜索和检索直到2022年5月进行的观察和实验研究。包括ISIWebofScience,科克伦,科学直接,Scopus,Pub-Med,谷歌学者。使用Stata15统计软件进行数据分析。
■最初的搜索产生了794篇文章,在消除重复后,这些文章随后减少到427篇文章。在应用纳入和排除标准后,共有16项研究纳入荟萃分析.与第二个四分位数中的第一个四分位数相比,前列腺癌的比值比为1.03(0.95-1.12),第三个四分位数为1.12(0.99-1.26),第四个四分位数为1.16(0.79-1.70)。关于发表偏倚发生概率的调查,Begg's和Egger's检验结果无统计学意义.
■尽管暴露于镉会导致前列腺癌的机会增加,这种机会增加没有统计学意义.
UNASSIGNED: Cadmium, a toxic heavy metal, experienced a surge in production during the 20th century due to the rise of nickel-cadmium batteries, metal plating, and plastic stabilizers. Exposure to cadmium primarily occurs through the consumption of contaminated food, such as vegetables and grains, as well as drinking water or inhaling polluted air. The objective of this study was to investigate the relationship between cadmium exposure and the incidence of
prostate cancer using a systematic
review and meta-analysis approach.
UNASSIGNED: This research involved searching and retrieving observational and experimental studies conducted until May 2022 from various databases, including ISI Web of Science, Cochrane, Science Direct, Scopus, Pub-Med, and Google Scholar. Data analysis was performed using Stata 15 statistical software.
UNASSIGNED: The initial search yielded 794 articles, which were subsequently reduced to 427 articles after eliminating duplicates. Following the application of inclusion and exclusion criteria, a total of 16 studies were included in the meta-analysis. The odds ratio of
prostate cancer compared to the first quartile of exposure in the second quartile was 1.03 (0.95-1.12), in the third quartile it was 1.12 (0.99-1.26) and in the fourth quartile of exposure was equal to 1.16 (0.79-1.70). Regarding the investigation of the probability of the occurrence of publication bias, the results of Begg\'s and Egger\'s tests were not statistically significant.
UNASSIGNED: Although exposure to cadmium leads to an increase in the chance of
prostate cancer, this chance increase was not statistically significant.