• 文章类型: Journal Article
    在头颈部手术中,经口机器人手术(TORS)正在发展成为口咽良性和恶性病变的关键治疗选择。即便如此,术后疼痛是TORS后的主要早期主诉之一.建立良好的循证程序特异性疼痛治疗指南可用于各种其他外科专业。然而,没有TORS的指导方针。
    本综述描述了在休息和手术相关活动期间TORS后早期疼痛强度的可用数据。
    关于TORS术后即刻疼痛的文献来自两个文献数据库。
    关于TORS后疼痛强度的大多数数据是基于数字评定量表,例如视觉模拟量表和/或镇痛需求。只有一项随机临床试验可用,反映文献主要基于回顾性研究和一些前瞻性研究。只有一项研究分析了相关功能期间的疼痛,即吞咽。总的来说,这些研究受到非标准化方法的困扰,并且需要有关疼痛评级和方法的时间安排的透明信息.
    最佳疼痛控制的证据有限,特别是在手术相关活动期间。活动过程中的术后疼痛评分是疼痛试验中的基本要素,以增强恢复,从而呼吁在评估方法上达成共识。
    UNASSIGNED: In Head and Neck surgery Transoral Robotic Surgery (TORS) is evolving as a key treatment option for benign and malignant lesions in the oropharynx. Even so, postoperative pain is one of the primary early complaints following TORS. Well established evidence-based procedure specific pain treatment guidelines are available for a variety of other surgical specialties. However, there are no guidelines for TORS.
    UNASSIGNED: This review describes the available data of early pain intensity following TORS during rest and procedure related activity.
    UNASSIGNED: Literature concerning pain in the immediate postoperative phase following TORS were obtained from two literature databases.
    UNASSIGNED: Most data on pain intensity following TORS are based upon a numeric rating scale, e.g. the Visual Analogue Scale and/or analgesic demands. Only one randomized clinical trial is available reflecting that the literature is mainly based on retrospective and a few prospective studies. Only one study analyzed pain during relevant functionality, i.e. swallowing. Overall, the studies suffer from a non-standardized approach and there is a need for transparent information concerning the timing of pain ratings and methodology.
    UNASSIGNED: The evidence for optimal pain control is limited, particularly during surgical relevant activity. Postoperative pain rating during activity is a fundamental element in pain trials in order to enhance recovery thereby calling for future consensus on assessment methodology.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    Human papilloma virus testing for oropharyngeal squamous-cell carcinoma has been recommended by the National Comprehensive Cancer Network since 2012. We examine disparities, reported rates of human papillomavirus (HPV) testing, and the impact on these findings of limitations with the variable in database registries.
    The HPV variable was queried for patients with oropharyngeal squamous carcinoma (OPSCC) from 2013 to 2016 in National Cancer Data Base (NCDB) and Surveillance, Epidemiology, and End Results (SEER). Multivariable regression was used to identify disparities based on sociodemographic variables. Sensitivity analyses were used to investigate limitations of the variable.
    Despite limitations in the HPV variable in the databases, there was less than 100% adherence to recommended testing, and there were significant disparities in multiple sociodemographic variables. For example, in NCDB 70% of white versus 60.4% of black patients were tested (odds ratio [OR] 0.75, confidence interval [CI] 0.66-0.85, p ≤ 0.0001); in SEER 59.8% of white and 47.6% of black patients were tested (OR 0.73, CI 0.67-0.81; p ≤ 0.0001).
    Disparities exist among patients undergoing testing for HPV-associated OPSCC and adherence to guideline recommended HPV testing has been suboptimal. In addition, the HPV variable definition, especially as it relates to p16 positivity, and use in these two registries should be improved.
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  • 文章类型: Journal Article
    Head and neck cancers (HNC) are defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2017 publication, the Spanish Society of Medical Oncology (SEOM) presents an update of the squamous cell HNC diagnosis and treatment guideline. Most relevant diagnostic and therapeutic changes from the last guideline have been updated: introduction of sentinel node biopsy in early oral/oropharyngeal cancer treated with surgery, concomitant radiotherapy with weekly cisplatin 40 mg/m2 in the adjuvant setting, new approaches for HPV-related oropharyngeal cancer and new treatments with immune-checkpoint inhibitors in recurrent/metastatic disease.
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  • 文章类型: Journal Article
    口咽鳞状细胞癌的近期历史治疗通常包括有/没有化疗的放疗。机器人手术等新型手术技术使初级手术更加频繁;然而,建议术后放疗。我们旨在评估机器人手术后对术后治疗指南的依从性。
    使用国家癌症数据库,我们分析了机器人手术后cT1-3cN0-2cM0口咽鳞状细胞癌的放疗频率,特别是在存在广泛接受的术后放疗和/或化疗适应症的情况下。
    大约三分之二的患者在机器人手术后接受了早期中期口咽癌的放疗。五分之一有辅助放疗指征的患者和三分之一有辅助化疗指征的患者未接受推荐的辅助治疗。
    对于早期中期口咽癌,机器人手术后需要放疗的患者比例很高。有进一步辅助治疗指征的患者通常不接受它。
    Recent historical management of oropharyngeal squamous cell carcinoma typically includes radiotherapy with/without chemotherapy. Novel surgical techniques such as robotic surgery have made primary surgery more frequent; however, postoperative radiotherapy may be recommended. We aimed to assess adherence to guidelines for postoperative therapy following robotic surgery.
    Using the National Cancer Database, we analyzed the frequency of radiotherapy following robotic surgery for cT1-3cN0-2cM0 squamous cell carcinoma of the oropharynx, specifically in the presence of widely accepted indications for postoperative radiotherapy and/or chemotherapy.
    Approximately two-thirds of patients received radiotherapy after robotic surgery for early-intermediate stage oropharyngeal cancer. One in five patients with an indication for adjuvant radiotherapy and 1/3 with an indication for adjuvant chemotherapy did not receive recommended adjuvant therapy.
    A high proportion of patients require radiotherapy after robotic surgery for early-intermediate stage oropharyngeal cancer. Patients with an indication for further adjuvant therapy commonly do not receive it.
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  • 文章类型: Journal Article
    Oral and oropharyngeal squamous cell carcinomas are the most common malignant tumours of the oral and maxillofacial region. A standardized pathological diagnosis report for oral and oropharyngeal squamous cell carcinoma should provide not only the pathological diagnosis itself as much accurate as possible, but also the information related to assessment of prognosis and strategy of treatment for the patient. An expert group organized by Society of Oral Pathology, Chinese Stomatological Association has set a guideline for the tissue fixation, gross examination and format of the pathological diagnosis report of oral and oropharyngeal squamous cell carcinoma. The guideline covers the important changes in clinical and pathological aspects of oral and oropharyngeal squamous cell carcinomas in recent years, such as depth of invasion in T category, extranodal extension in N category and human papilloma virus-associated squamous cell carcinoma in oropharyngeal carcinomas. Hopefully the guideline will improve the quality of pathological reports of oral and oropharyngeal squamous cell carcinomas and provide reliable data on clinical therapy and prognosis evaluation of patients with oral and oropharyngeal squamous cell carcinomas in China.
    口腔癌及口咽癌是口腔颌面部最常见的恶性肿瘤。规范化的口腔癌及口咽癌病理诊断报告不仅应提供给临床准确的病理诊断,还应包括与患者预后评估、治疗策略选择相关的信息。由中华口腔医学会口腔病理学专业委员会牵头组织成立专家组,对口腔癌及口咽癌病理标本固定、取材及报告内容等进行研讨与规范,形成《口腔癌及口咽癌病理诊断规范》。此规范涵盖了近年来在口腔癌和口咽癌临床病理方面的一些重要变化,如口腔癌肿瘤T分期应考虑肿瘤侵袭深度、肿瘤N分期应考虑有无淋巴结外扩展、口咽癌中新亚型人乳头状瘤病毒相关性鳞状细胞癌等。希望通过本规范的制定,提高我国口腔癌及口咽癌病理报告质量,为临床治疗及预后评估提供依据。.
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  • 文章类型: Journal Article
    OBJECTIVE: A multidisciplinary team (MDT) approach to cancer management is gold-standard. With an increasing disease incidence and growing research into human papillomavirus (HPV)-related oropharyngeal cancer (OPC), updated UK management guidelines were recently published. This study aimed to evaluate the MDT decision-making process among OPC patients at a tertiary centre.
    METHODS: MDT meetings over a 12-month period were analysed retrospectively. MDT decisions were compared with guidelines and patient records examined to identify decision implementation. Reasons behind any discordant decisions were explored.
    RESULTS: This study included 140 OPC patients. Thirty-three (23.6%) were not tested for HPV. Patients over 70 years with a smoking history treated palliatively were less likely to be tested (P = 0.017). Eighty-five percent of MDT decisions followed guidelines with the majority not complying (76.2%) related to patient comorbidity. Ten decisions (7.1%) were not implemented. Reasons included: Seven due to patient choice, of which four patients (57.1%) were only seen following the MDT meeting, and three due to clinician decisions as new clinical information emerged.
    CONCLUSIONS: The majority of MDT decisions followed guidelines and any discordant decisions were justifiable. Discussing management options with patients beforehand facilitates decision implementation as decisions can potentially change after seeing the patient. Progress is still needed with regards to HPV testing. Reasons for not testing could include subliminal decision-making among clinicians, and patients falling between centres. Crucially, the role of the MDT in head and neck cancer should be to ratify decisions rather than making them, hence the need to see patients prior to MDT discussion.
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  • 文章类型: Journal Article
    目的:作者介绍了法国耳鼻咽喉科学会-头颈外科学会关于宫颈囊性肿块的淋巴结病诊断程序的指南。
    方法:委托一个多学科工作组对该主题的科学文献进行综述。制定了指导方针,然后由独立于工作组的编辑小组阅读,最终版本被起草。指南被评为A级,B,C或专家意见,通过降低证据水平。
    结果:在呈现囊性宫颈肿块的成年人中,建议怀疑颈淋巴结病:按频率降低的顺序,头颈部鳞状细胞癌的囊性转移,未分化鼻咽癌,甲状腺乳头状癌(C级)。超声检查发现宫颈囊性肿块,应筛查显示淋巴结和甲状腺结节的建筑元素,特别是如果质量位于III级,IV或VI(A级)。如果在CT上有囊性成分的宫颈肿块(B级),则应怀疑恶性淋巴结病。但是良性或恶性状态不能仅根据放射学数据(CT或MRI)(A级)来诊断,应进行18-FDGPET-CT,特别是在超声引导下细针穿刺活检(C级)不确定的情况下。
    OBJECTIVE: The authors present the guidelines of the French Society of Otorhinolaryngology - Head and Neck Surgery Society on diagnostic procedures for lymphadenopathy in case of a cervical mass with cystic aspect.
    METHODS: A multidisciplinary work-group was entrusted with a review of the scientific literature on the topic. Guidelines were drawn up, then read over by an editorial group independent of the work-group, and the final version was drawn up. Guidelines were graded as A, B, C or expert opinion, by decreasing level of evidence.
    RESULTS: In adults presenting a cystic cervical mass, it is recommended to suspect cervical lymphadenopathy: in order of decreasing frequency, cystic metastasis of head and neck squamous cell carcinoma, of undifferentiated nasopharyngeal carcinoma, and of thyroid papillary carcinoma (Grade C). On discovery of a cystic cervical mass on ultrasound, architectural elements indicating a lymph node and a thyroid nodule with signs of malignancy should be screened for, especially if the mass is located in levels III, IV or VI (Grade A). Malignant lymphadenopathy should be suspected in case of cervical mass with cystic component on CT (Grade B), but benign or malignant status cannot be diagnosed only on radiological data (CT or MRI) (Grade A), and 18-FDG PET-CT should be performed, particularly in case of inconclusive ultrasound-guided fine needle aspiration biopsy (Grade C).
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