■延迟性神经精神后遗症(DNS)是一种在急性一氧化碳(CO)中毒后数天至数周出现的综合征。DNS显示各种神经精神症状,如精神退化和帕金森病。
我们的病例是一名37岁男性精神分裂症患者。他试图通过CO中毒自杀,并被带到我们的急诊室(第0天)。他接受了常压氧疗通气3天,并以清醒的意识转移到精神病房。我们重新开始抗精神病药,他逐渐表现出运动障碍和僵硬。此外,在第32天左右,他表现出杂乱无章的行为,精神恶化,失禁,和步态紊乱。脑磁共振成像(MRI)在第35天显示轻微异常发现。尽管我们在临床过程和MRI检查结果中怀疑DNS,还考虑了抗精神病药的卡顿和副作用。最后,第38天脑电图(EEG)有明显异常,包括扩散慢波,导致我们对DNS的诊断,他接受了高压氧治疗.他的病情有了很大的改善,他在脑电图上的弥散慢波在第83天消失了。我们还跟踪了他的临床表现和脑部MRI,直到33个月。在整个后续行动中,他的认知,运动,精神症状保持稳定。然而,他的脑MRI显示双侧额叶进行性萎缩,整个过程中白质病变增加。
■脑电图,以及脑部MRI,在涉及药物治疗和严重精神疾病的复杂疾病患者中,DNS的鉴别诊断可能至关重要。
UNASSIGNED: Delayed neuropsychiatric sequelae (DNS) is a syndrome that appears days to weeks after acute carbon monoxide (CO) poisoning. DNS shows various neuropsychiatric symptoms, such as mental deterioration and parkinsonism.
UNASSIGNED: Our
case was a 37-year-old male with schizophrenia. He attempted suicide by CO poisoning and was brought to our emergency department (Day 0). He was ventilated with normobaric oxygen therapy for 3 days and moved to the psychiatric ward with clear consciousness. We restarted antipsychotics, and he gradually presented akinesia and rigidity. Additionally, around Day 32, he showed disorganized behaviors, mental deterioration, incontinence, and gait disturbance. Brain magnetic resonance imaging (MRI) showed slightly abnormal findings on Day 35. Although we suspected DNS on the clinical course and the MRI findings, catatonia and side-effects of antipsychotics were also considered. Finally,
electroencephalography (EEG) on Day 38 with apparent abnormalities, including diffuse slow waves, resulted in our diagnosis of DNS, and he underwent hyperbaric oxygen therapy. His condition was dramatically improved, and his diffuse slow waves on EEG disappeared on Day 83. We also followed his clinical presentations and brain MRI until 33 months. Throughout the whole follow-up, his cognition, movement, and psychiatric symptoms remained stable. However, his brain MRI showed progressive atrophy in bilateral frontal lobes and increasing white matter lesions throughout the whole course.
UNASSIGNED: EEG, as well as brain MRI, may be crucial in the differential diagnosis of DNS in patients with complex conditions involving medications and severe mental illnesses.