结论:体内稳态的丧失和慢性炎症导致干眼的眼表损害,在确定的病例中,这也与角膜变薄有关。然而,角膜厚度与新的干眼病例之间的相关性仍然没有得到足够的证据支持.
目的:本研究旨在比较新发干眼病例与年龄和性别匹配的对照组的中央角膜厚度。
方法:将45例干眼症患者与61例年龄和性别匹配的非干眼症患者进行比较。眼表疾病指数(OSDI)问卷用于评估症状,用NidekCEM-530镜面反射显微镜测量中央角膜厚度。根据疾病严重程度(OSDI评分)对患者进行分组,两组间比较裂隙灯检查的临床表现,Schirmer\'sItest,和泪膜破裂时间。
结果:患者的中位年龄为25.0(四分位距[IQR],20.0至32.0)和27.0(IQR,对照组和干眼症组20.0至32.0)年,分别(p=0.63)。OSDI分数的中位数(IQR)值,泪膜破裂时间分数,对照组的Schirmer测试测量值为10.4(8.3至10.4),12.0(11.0到14.0)秒,和16.0(13.5至19.5)毫米,分别,这与干眼症组不同(p<0.0001)。干眼症组的这些值是29.1(25.0至39.5),4.0(3.0到8.0)秒,和8.0(3.5至11.0)毫米,分别。干眼患者的中央角膜厚度低于对照组(p<0.01)。干眼症患者和对照组的平均±标准差中央角膜厚度分别为520.3±26.8和545.3±18.8μm,分别。
结论:干眼症的中央角膜厚度与对照组相比明显降低。这些发现可能有助于监测和管理干眼,应在眼内压测量和屈光手术中予以考虑。
CONCLUSIONS: Loss of homeostasis and chronic inflammation result in ocular surface damage in dry eyes, which is also associated with corneal thinning in established cases. Yet, the correlation between corneal thickness and new cases of dry eyes remains inadequately supported by evidence.
OBJECTIVE: This study aimed to compare the central corneal thickness of new cases of dry eyes to that of age- and gender-matched controls.
METHODS: A total of 45 dry eye patients were compared with 61 age- and gender-matched non-dry eye individuals. The Ocular Surface Disease Index (OSDI) questionnaire was used to evaluate symptoms, and the central corneal thickness was measured with a Nidek CEM-530 specular microscope. Patients were grouped based on disease severity (OSDI scores), and the clinical findings were compared between groups for slit-lamp examinations, Schirmer\'s I test, and tear film breakup time.
RESULTS: The median age of patients was 25.0 (interquartile range [IQR], 20.0 to 32.0) and 27.0 (IQR, 20.0 to 32.0) years in the control and dry eye groups, respectively (p=0.63). The median (IQR) values of the OSDI scores, tear film breakup time scores, and Schirmer\'s test measurements in the control groups were 10.4 (8.3 to 10.4), 12.0 (11.0 to 14.0) seconds, and 16.0 (13.5 to 19.5) mm, respectively, which differed from the dry eye groups (p<0.0001). These values in the dry eye group were 29.1 (25.0 to 39.5), 4.0 (3.0 to 8.0) seconds, and 8.0 (3.5 to 11.0) mm, respectively. Patients with dry eyes had lower central corneal thickness than controls (p<0.01). The mean ± standard deviation central corneal thicknesses in patients with dry eyes and the control group were 520.3 ± 26.8 and 545.3 ± 18.8 μm, respectively.
CONCLUSIONS: The central corneal thickness in dry eyes was significantly reduced compared with the control group. These findings may be useful in monitoring and managing dry eyes and should be considered in intraocular pressure measurements and refractive surgical procedures.