目的:总结老年胃癌患者术前虚弱危险因素的现有证据。
方法:我们全面搜索了CNKI,万方,VIP,CBM,PubMed,Embase,科克伦图书馆,WebofScience,术前文章和CINAHL数据库中老年胃癌患者虚弱的危险因素。搜索是从图书馆建造之时到2024年1月27日进行的,没有语言限制。纳入研究的质量由纽卡斯尔-渥太华量表和医疗保健研究和质量工具机构进行评级。
结果:共纳入20项研究,包括16项队列研究和4项横断面研究,总样本量为51,717人。荟萃分析的结果表明,年龄,白蛋白,血红蛋白,癌症III-IV期,Charlson合并症指数评分≥3,东部肿瘤协作组评分>2,美国麻醉医师协会评分>2,吸烟,营养风险,高中或以上学历,睡眠障碍是老年胃癌患者术前虚弱发生的主要影响因素。其中,高中以上学历是保护因素。
结论:我们的研究为老年胃癌患者术前虚弱的危险因素提供了有效的证据,并告知临床医护人员采取有针对性的干预措施。
OBJECTIVE: To summarize the available evidence on risk factors for preoperative frailty in older gastric cancer patients.
METHODS: We comprehensively searched the CNKI, Wanfang, VIP, CBM, PubMed, Embase, The Cochrane Library, Web of Science, and CINAHL databases for preoperative articles on risk factors for frailty in older gastric cancer patients. The search was conducted from the time of construction of the library to January 27, 2024, with no language restrictions. The quality of the included studies was rated by the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality tool.
RESULTS: A total of 20 studies were included, including 16 cohort studies and 4 cross-sectional studies, with a total sample size of 51,717 individuals. The results of the meta-analysis showed that age, albumin, hemoglobin, cancer stage III-IV, Charlson Comorbidity Index score ≥ 3, Eastern Cooperative Oncology Group score > 2, American Society of Anesthesiologists score > 2, smoking, nutritional risk, high school degree or above, and sleep disorders are the main influencing factors for the occurrence of preoperative frailty in older gastric cancer patients. Among them, high school degree or above was a protective factor.
CONCLUSIONS: Our study provides valid evidence of risk factors for preoperative frailty in older patients with gastric cancer and informs clinical healthcare professionals to make targeted interventions.