• 文章类型: Case Reports
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  • 文章类型: Case Reports
    背景:原发性肺脑膜瘤(PPM)是一种非常罕见的起源于肺内脑膜的肿瘤。尽管与中枢神经系统(CNS)相似,PPM由于其不经常发生而提出了独特的诊断挑战和治疗考虑。
    方法:本病例报告描述了一名73岁的男性,他接受了胸部计算机断层扫描(CT)检查,显示右下叶后基底段有肿块,提示约30-40毫米大小的低度恶性肿瘤。单孔电视胸腔镜手术(VATS)通过局部病灶切除(肺楔形切除术)切除肿块。术中冰冻切片病理提示低度恶性上皮性肿瘤,导致最大肺功能保留的决定,考虑到病人的高龄。手术团队选择了局部切除以确保阴性切缘。组织病理学分析证实了上皮样PPM的诊断,甚至在PPM病例中也是一种罕见的亚型(世界卫生组织[WHO]I级)。患者术后9天出院,无并发症发生,术后1个月恢复正常日常活动。PPM的稀有性排除了标准化的治疗方案,以手术切除为主要方法。然而,由于证据有限,辅助治疗的疗效仍不确定.
    结论:本病例报告有助于更好地理解PPM,并强调对这种罕见实体进行全面诊断评估和个体化治疗计划的重要性。
    BACKGROUND: Primary pulmonary meningioma (PPM) is an exceedingly rare neoplasm originating in the meninges within the lung. Despite sharing similarities with its central nervous system (CNS) counterparts, PPM presents unique diagnostic challenges and therapeutic considerations owing to its infrequent occurrence.
    METHODS: This case report describes a 73-year-old male who underwent chest computed tomography (CT), which revealed a mass in the posterior basal segment of the right lower lobe, suggestive of a low-grade malignant tumor approximately 30-40 mm in size. Single-port video-assisted thoracoscopic surgery (VATS) was performed to resect the mass via localized lesion excision (lung wedge resection). Intraoperative frozen section pathology indicated a low-grade malignant epithelial tumor, leading to a decision for maximal lung function preservation, considering the patient\'s advanced age. The surgical team opted for a localized excision to ensure negative margins. Histopathological analysis confirmed the diagnosis of epithelioid PPM, a rare subtype even among PPM cases (World Health Organization [WHO] Grade I). The patient was discharged 9 days after surgery without complications and resumed normal daily activities 1 month postoperatively. The rarity of PPM precludes a standardized treatment protocol, with surgical resection as the primary approach. However, the efficacy of adjunctive therapies remains uncertain due to limited evidence.
    CONCLUSIONS: This case report contributes to a better understanding of PPM and emphasizes the importance of a comprehensive diagnostic evaluation and individualized treatment planning for this rare entity.
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  • 文章类型: Case Reports
    背景:当支气管和胸膜腔之间形成异常连接时,会发生支气管胸膜瘘(BPF),通常由于手术,感染,创伤,辐射,或化疗。手术和支气管镜治疗的结果经常被证明是不令人满意的。
    方法:这里,我们报告1例成功的支气管镜下游离脂肪垫移植联合富血小板血浆,有效解决肺叶切除术后的BPF。对比增强胸部体层摄影术显示右上叶和中叶胸膜增厚伴异质巩固,指示破坏性肺损伤和支气管扩张。患者接受了胸腔镜下肺的双叶切除术。手术期间,观察到胸壁和肺实质的严重粘连和钙化。整个肺门结构钙化,给解剖带来挑战,尽管有能源设备的帮助。需要支气管镜干预,在此期间取回了两个腹部皮下脂肪垫。
    结论:这一创新方法为BPF的管理提供了希望,并标志着在提高治疗效果和患者康复方面的潜在进步。
    BACKGROUND: A bronchopleural fistula (BPF) occurs when an abnormal connection forms between the bronchial tubes and pleural cavity, often due to surgery, infection, trauma, radiation, or chemotherapy. The outcomes of both surgical and bronchoscopic treatments frequently prove to be unsatisfactory.
    METHODS: Here, we report a case of successful bronchoscopic free fat pad transplantation combined with platelet-rich plasma, effectively addressing a post-lobectomy BPF. Contrast-enhanced chest tomography revealed pleural thickening with heterogeneous consolidations over the right upper and middle lobes, indicative of destructive lung damage and bronchiectasis. The patient underwent thoracoscopic bilobectomy of the lungs. During surgery, severe adhesions and calcification of the chest wall and lung parenchyma were observed. The entire hilar structure was calcified, presenting challenges for dissection, despite the assistance of energy devices. Bronchoscopic intervention was required, during which two abdominal subcutaneous fat pads were retrieved.
    CONCLUSIONS: This innovative approach offers promise in the management of BPF and signals potential advancements in enhancing treatment efficacy and patient recovery.
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  • 文章类型: Case Reports
    背景:气胸是胸膜腔中空气的非生理性集合。气胸可大致分为原发性,次要,和创伤。肺癌是原发性和转移性病变继发性气胸的已知原因,然而,气胸作为肺癌的表现极为罕见。文献报道非小细胞肺癌(NSCLC)存在气胸,特别是在腺/鳞状细胞癌。小细胞肺癌(SCLC)出现气胸几乎是闻所未闻的。
    方法:我们介绍了一个62岁的男性患者,在两个月内出现两次自发性气胸。最初的管理包括入院和胸腔引流。该患者具有COPD的既往病史和明显的吸烟史。在第二次入场时,他接受了电视辅助胸腔镜(VATS)大泡切除术和滑石粉胸膜固定术。切除标本的病理报告证实SCLC有广泛浸润。CT上没有转移扩散的明显证据。由于R1切除和显著的复发风险,管理计划包括卡铂和依托泊苷辅助化疗四个周期,和放射治疗作为完成后的考虑因素。
    结论:气胸作为肺癌的表现预后极差,然而,其原因在很大程度上是未知的。此外,肺癌自发性气胸的潜在机制也不清楚.
    BACKGROUND: Pneumothorax is a non-physiological collection of air in the pleural space. Pneumothoraces can be broadly divided into Primary, Secondary, and Traumatic. Cancer of the lung is a known cause of secondary pneumothorax in both primary and metastatic lesions, however, pneumothorax as the presentation of lung cancer is exceedingly rare. Non-small cell lung carcinoma (NSCLC) has been reported in the literature to present with a pneumothorax, particularly in adeno/squamous cell carcinomas. It is almost completely unheard of for small cell lung carcinoma (SCLC) to present with a pneumothorax.
    METHODS: We present the case of a 62-year-old male patient, presenting twice in two months with spontaneous pneumothorax. The initial management involved admission and chest drain insertion. The patient has a past medical history of COPD and a significant smoking history. On the second admission, he underwent a video-assisted thoracoscopic (VATS) bullectomy and talc pleurodesis. The pathology report of the resected specimen confirmed SCLC with extensive infiltration. No gross evidence of metastatic spread was present on CT. Due to the R1 resection and significant risk of recurrence, the management plan included four cycles of adjuvant chemotherapy with carboplatin and etoposide, and radiotherapy as a consideration upon completion.
    CONCLUSIONS: Pneumothorax as the presentation of lung cancer imparts a very poor prognosis, however the reasons for this are largely unknown. Furthermore, the mechanisms underlying spontaneous pneumothorax in lung cancer are also not well understood.
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  • 文章类型: Case Reports
    自发性气胸是胸外科手术中最常见的疾病之一。这种情况可以根据适应症和指南保守或手术治疗。传统的手术治疗包括胸膜固定术(机械或化学),如果可以识别大疱,除了大疱切除术。机械胸膜固定术通常通过手术胸膜切除术或胸膜擦伤进行。在这个案例报告中,我们介绍了1例发生自发性气胸的年轻患者,该患者需要手术治疗.我们表演了一个新的,外科胸膜切除术的创新手术技术,其中我们使用二氧化碳解剖顶叶胸膜(导管解剖)。这种技术可以提供与传统手术相似的效率,但出血和并发症的风险较小。
    Spontaneous pneumothorax is one of the most common conditions encountered in thoracic surgery. This condition can be treated conservatively or surgically based on indications and guidelines. Traditional surgical management includes pleurodesis (mechanical or chemical) in addition to bullectomy if the bullae can be identified. Mechanical pleurodesis is usually performed by surgical pleurectomy or pleural abrasion. In this case report, we present a case of a young patient with spontaneous pneumothorax who needed a surgical intervention. We performed a new, innovative surgical technique for surgical pleurectomy where we used carbon dioxide for dissection of the parietal pleura (capnodissection). This technique may provide similar efficiency to the traditional procedure but with less risk of bleeding and complications.
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  • 文章类型: Case Reports
    左心耳封堵器(LAAO)移位并栓塞是罕见的。如果LAAO迁移到左心房或心室,它会导致急性心力衰竭甚至死亡,需要紧急手术干预。目前,大多数LAAO移位病例是通过心脏直视手术治疗的,而仅在少数相关经验有限的病例中报道了LAAO的经皮取回。本文报告了一例患者,其中使用基于导管的方法成功取回了迁移的LACbes装置。展示创新和微创治疗策略。
    Left atrial appendage occluder (LAAO) dislodgement with embolization is a rare occurrence. If the LAAO migrates into the left atrium or ventricle, it can lead to acute heart failure or even death in a person, necessitating urgent surgical intervention. Currently, most cases of LAAO dislodgement are managed through open-heart surgery, while percutaneous retrieval of the LAAO has been reported only in a few cases with limited associated experience. This article reports a case of a patient in whom a migrated LACbes device was successfully retrieved using a catheter-based approach, demonstrating an innovative and minimally invasive treatment strategy.
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  • 文章类型: Case Reports
    中间链球菌在传染病中的意义,尤其是胸膜感染,正在获得认可。虽然传统的风险因素,如牙科手术和免疫抑制仍然是鉴别诊断的关键,人们逐渐认识到与S.intermedius感染相关的非常规临床表现和危险因素.这种转变迫使医疗专业人员扩大他们的诊断和治疗策略,强调管理与这种机会性细菌相关的感染的复杂和不断发展的性质。我们描述了一名48岁的免疫功能正常的女性,患有未经治疗的高血压,经历了15天的右侧胸痛发作,随着呼吸困难的突然发作而恶化,然而,她的日常活动仍然没有受到影响。体格检查提示胸膜肺综合征是由于明显的胸腔积液,肺部计算机断层扫描(CT)扫描显示右侧约有50%的积液。实验室检查提示炎症标志物升高。超声引导胸腔穿刺术提取与脓胸相容的化脓液,需要使用阿替普酶放置胸膜引流和多次胸膜腔灌洗,这导致大量感染液体的去除。胸膜液培养鉴定为中间链球菌,是泛敏感的。给予静脉注射头孢曲松治疗,导致良好的临床结果。此病例强调了识别非典型临床表现和管理胸膜腔中复杂细菌感染的关键性质。
    The significance of Streptococcus intermedius in infectious diseases, especially pleural infections, is gaining recognition. While traditional risk factors like dental procedures and immunosuppression remain pivotal in differential diagnosis, there is an emerging recognition of unconventional clinical presentations and risk factors linked to infections by S. intermedius. This shift compels medical professionals to broaden their diagnostic and therapeutic strategies, underscoring the intricate and evolving nature of managing infections associated with this opportunistic bacterium. We describe the case of a 48-year-old immunocompetent woman with untreated hypertension who experienced a 15-day episode of right-sided chest pain, which worsened with a sudden onset of dyspnea, yet her daily activities remained unaffected. Physical examination suggested a pleuropulmonary syndrome due to significant pleural effusion, with a computed tomography (CT) scan of the lungs revealing about 50% effusion on the right side. Laboratory tests indicated elevated inflammatory markers. Ultrasound-guided thoracentesis extracted purulent fluid compatible with empyema, necessitating the placement of a pleural drain and multiple pleural cavity lavages using alteplase, which led to the removal of substantial infected fluid. Culture of the pleural fluid identified S. intermedius, which was pansusceptible. Treatment with intravenous ceftriaxone was administered, resulting in a favorable clinical outcome. This case highlights the critical nature of recognizing atypical clinical presentations and managing complex bacterial infections in the pleural space.
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  • 文章类型: Case Reports
    关于留在或植入体内的异物迁移的报道非常罕见,到目前为止,它们仅在胃肠道和肠道中被报道(类似于吞噬作用的过程),后来表现为管腔阻塞。同时,尚未在心血管系统中报告此类病例。此处报告的病例是一名14个月大的女孩,由于严重的肺动脉高压和无法茁壮成长,在8个月大的时候在肺动脉周围进行了肺动脉带(由PTFE制成的PA带)。六个月后,她接受了再次手术以进行最终治疗。发现PA带不再在肺动脉周围,已完全迁移到肺动脉中,同时保持完整和圆形,并以类似于吞噬作用的过程被吸引到肺动脉中。PA带被完全去除。切除主肺动脉内部的不平坦表面,并对动脉进行端到端修复。再次对患者进行全心脏修复手术。在第二次手术后的2.5年随访中未观察到问题。总的来说,作者的案例是在PA带植入后六个月发生的生物中性异物迁移到心血管系统的第一个实例,以及第一例异物侵蚀进入胃肠道外的管腔。尽管提交人找不到本案的原因,对未来案例的报告可以帮助找到根本原因。
    There have been very rare reports on the migration of foreign bodies that are left or implanted in the body, and so far, they have only been reported in the gastrointestinal tract and intestines (a process similar to phagocytosis), later manifesting as an obstruction in the lumen. Meanwhile, no such cases have yet been reported in the cardiovascular system. The case reported here is a 14-month-old girl who had undergone pulmonary artery banding (PA band made of PTFE) around the pulmonary artery at the age of 8 months due to severe pulmonary hypertension and failure to thrive. She underwent reoperation six months later for a final treatment. It was discovered that the PA band was no longer around the pulmonary artery and had migrated completely into the pulmonary artery while remaining intact and circular and was drawn into the pulmonary artery in a process similar to phagocytosis. The PA band was removed completely. The uneven surface inside the main pulmonary artery was resected and the artery was repaired end-to-end. A total heart repair surgery was again performed on the patient. No problem was observed in the 2.5-year follow-up after the second surgery. Overall, the authors\' case is the first instance of migration of a biologically-neutral foreign body into the cardiovascular system that had occurred six months after the PA-band implantation, and the first case of erosion of a foreign body into the lumen outside the gastrointestinal tract. Although the authors could not find the cause of the presented case, reports on future cases can help find the underlying reason.
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  • 文章类型: Journal Article
    脆弱预测手术患者的预后较差。最近的研究发现,社会经济地位是手术结果的重要特征。我们评估了区域剥夺指数(ADI)和社会脆弱性指数(SVI)的相关性,两个地理空间图集提供了对邻域剥夺的多维评估,在手术人群中身体虚弱。
    对接受常规虚弱筛查的患者进行了回顾性研究12/2020-8/2022。使用弗里德的虚弱表型(FFP)和五项改良虚弱指数(mFI-5)测量虚弱。使用患者住所确定ADI和SVI四分位数。使用Logistic回归模型评估FFP(仅虚弱vs不虚弱)和mFI-5(≥2vs0-1)与ADI和SVI的相关性(α=0.05)。
    在372名接受筛查的患者中,41%(154)是女性,中位年龄为68%(63-74),46%(170)被确定为非白人。在ADI和SVI四分位数中,更多的合并症,收入中位数下降,虚弱与剥夺感增加有关(p<0.01)。当控制年龄时,性别,合并症,和BMI类别,FFP的虚弱与ADI的最剥夺的两个四分位数有关(OR2.61,CI:[1.35-5.03],p<0.01)和SVI的最剥夺四分位数(OR2.33,[1.10-4.95],p<0.05)。这些趋势也可见于mFI-5评分≥2(ADI:OR1.64,[1.02-2.63],p<0.05;SVI:OR1.71,[1.01-2.91],p<0.05)。
    生活在社会经济贫困社区的手术患者更容易虚弱。干预措施可能包括对弱势群体进行筛查,并将资源分配给弱势群体。
    UNASSIGNED: Frailty predicts poorer outcomes in surgical patients. Recent studies have found socioeconomic status to be an important characteristic for surgical outcomes. We evaluated the association of Area Deprivation Index (ADI) and Social Vulnerability Index (SVI), two geospatial atlases that provide a multidimensional evaluation of neighborhood deprivation, with frailty in a surgery population.
    UNASSIGNED: A retrospective study of patients undergoing routine frailty screening was conducted 12/2020-8/2022. Frailty was measured using Fried\'s Frailty Phenotype (FFP) and the five-item Modified Frailty Index (mFI-5). ADI and SVI quartiles were determined using patient residence. Logistic regression models were used to evaluated associations of FFP (frail only vs not frail) and mFI-5 (≥2 vs 0-1) with ADI and SVI (α = 0.05).
    UNASSIGNED: Of 372 screened patients, 41% (154) were women, median age was 68% (63-74), and 46% (170) identified as non-White. Across ADI and SVI quartiles, higher number of comorbidities, decreasing median income, and frailty were associated with increasing deprivation (p < 0.01). When controlling for age, sex, comorbidities, and BMI category, frailty by FFP was associated with the most deprived two quartiles of ADI (OR 2.61, CI: [1.35-5.03], p < 0.01) and the most deprived quartile of SVI (OR 2.33, [1.10-4.95], p < 0.05). These trends were also seen with mFI-5 scores ≥2 (ADI: OR 1.64, [1.02-2.63], p < 0.05; SVI: OR 1.71, [1.01-2.91], p < 0.05).
    UNASSIGNED: Surgical patients living in socioeconomically deprived neighborhoods are more likely to be frail. Interventions may include screening of disadvantaged populations and resource allocation to vulnerable neighborhoods.
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  • 文章类型: Case Reports
    胆总管胆管癌(CBD)表现为胆囊脓胸是一种罕见的实体,具有败血症的风险,感染性休克,腹膜炎,和脓肿形成。该病例报告描述了一名老年女性,其右侧软骨下出现疼痛,墨菲的积极迹象,有反流和便秘史.它强调了影像学在早期诊断这种罕见的潜在恶性肿瘤中的价值。胆囊脓胸的最常见原因是急性胆囊炎,接着是胆囊颈部结石阻塞.本报告讨论了临床病史支持的影像学的重要作用,考试,实验室测试,和组织病理学发现,以诊断这种罕见的胆囊脓胸为潜在胆管癌的并发症。此外,简要讨论了胆管癌合并胆囊穿孔、败血症等并发症患者治疗路线的改变。该研究得出的结论是,在症状相似的患者中,潜在的胆管恶性肿瘤的可能性不可忽视。尤其是老年人。
    Cholangiocarcinoma of the common bile duct (CBD) presenting as empyema of the gallbladder is a rare entity that poses a risk of septicemia, septic shock, peritonitis, and abscess formation. This case report describes an elderly female presenting with pain in the right hypochondrium, a positive Murphy\'s sign, and a history of regurgitation and constipation. It highlights the value of imaging in the early diagnosis of this rare presentation of underlying malignancy. The most common cause of empyema of the gallbladder is acute cholecystitis, followed by gallbladder neck obstruction by a calculus. This report discusses the important role of imaging supported by clinical history, examination, laboratory tests, and histopathological findings to diagnose this rare presentation of empyema of the gallbladder as a complication of underlying cholangiocarcinoma. Additionally, it briefly discusses the change in the management line for cholangiocarcinoma patients with complications such as gallbladder perforation and septicemia. The study concludes that the possibility of underlying bile duct malignancy cannot be overlooked in patients with similar symptoms, particularly among the elderly.
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