■研究多囊卵巢综合征(PCOS)与高尿酸血症之间的潜在关联,并阐明潜在的促成因素。
■对603名PCOS女性和604名无PCOS女性进行回顾性研究。人体测量特征,生殖激素概况,测量并比较两组患者的代谢参数。对SUA水平和其他参数之间的相关性进行检查以辨别潜在的相关性。
与没有PCOS的女性相比,PCOS女性的血清尿酸水平和高尿酸血症的发生率均显示出统计学上的显着升高。尽管如此,根据体重指数(BMI)对研究对象进行分层后,肥胖亚组之间未发现这种统计学差异.Pearson的相关分析强调了BMI作为影响女性SUA水平的一个强有力的因素,无论其PCOS状态如何。此外,多变量线性回归模型表明SUA水平与几个变量之间存在显著正相关,即硫酸脱氢表雄酮(DHEA-S),游离雄激素指数(FAI),总胆固醇(TC),甘油三酯(TG),游离脂肪酸(FFA),空腹胰岛素(FINS),胰岛素抵抗的稳态模型评估(HOMA-IR),胰岛素曲线下面积(AUC-I),丙氨酸氨基转移酶(ALT),和天冬氨酸氨基转移酶(AST)。此外,值得注意的是,高尿酸血症的患病率与空腹血糖(FPG)水平呈正相关,而反过来,它与雌二醇(E2)水平呈负相关。
■PCOS与SUA水平显著升高和高尿酸血症患病率相关。HA,IR,血脂异常可能是PCOS女性高尿酸血症发病的介质。
UNASSIGNED: To examine the potential association between polycystic ovary syndrome (PCOS) and
hyperuricemia and to elucidate the underlying contributory factors.
UNASSIGNED: Retrospective study on 603 women with PCOS and 604 women without PCOS. Anthropometric features, reproductive hormone profiles, and metabolic parameters were measured and compared between two groups of patients. Examinations of correlations between SUA levels and other parameters were conducted to discern potential correlations.
UNASSIGNED: Both serum uric acid levels and the incidence of hyperuricemia exhibited statistically significant elevations in women with PCOS when compared to their counterparts without PCOS. Nonetheless, this statistical difference was not found between the obese subgroup after stratifying study subjects by body mass index (
BMI). Pearson\'s correlation analysis underscored the prominence of
BMI as a robust factor influencing SUA levels in women, regardless of their PCOS status. Furthermore, multivariable linear regression model demonstrated significant positive associations between SUA levels and several variables, namely dehydroepiandrosterone sulfate (DHEA-S), free androgen index (FAI), total cholesterol (TC),
triglycerides (TG), free fatty acids (FFA), fasting insulin (FINS), homeostatic model assessment of insulin resistance (HOMA-IR), area under the curve for insulin (AUC-I), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Additionally, it is noteworthy that the prevalence of hyperuricemia exhibited a positive association with fasting plasma glucose (FPG) levels, while conversely, it displayed a negative association with estradiol (E2) levels.
UNASSIGNED: PCOS is associated with a significant elevation of SUA level and hyperuricemia prevalence. HA, IR, and
dyslipidemia may be the mediators in the pathogenesis of
hyperuricemia in women with PCOS.