背景:2型糖尿病高危人群患心血管疾病(CVD)的风险也增加。尽管有单独的试验研究生活方式干预对2型糖尿病高危人群绝对CVD风险的影响,缺乏这些试验的综合综合证据。
目的:我们将系统地综合有关生活方式干预在降低2型糖尿病高危人群中绝对CVD风险和CVD风险因素方面的作用的证据。
方法:在报告本方案的细节时,我们坚持PRISMA-P(系统评价和Meta分析方案的首选报告项目)声明。糖尿病预防的随机对照试验研究了生活方式干预至少6个月对2型糖尿病高危人群的绝对CVD风险和CVD风险因素的影响。我们将系统地搜索MEDLINE,Embase,PsycINFO,中部,和Scopus数据库和ClinicalTrials.gov使用医学主题词和文本词的混合。两位作者将独立筛选从搜索中检索到的文章的摘要和标题,随后使用纳入和排除标准进行全文综述,并从符合条件的研究中提取数据.文章筛选和数据提取将在Covidence软件中进行。主要结果将是10年CVD绝对风险的变化,由风险预测模型估计。次要结果是CVD危险因素的变化,包括行为,临床,生物化学,和心理社会危险因素,和2型糖尿病的发病率。
结果:在2023年7月进行了初步的数据库搜索。在筛选了1935篇通过数据库搜索确定的文章后,42篇文章被认为有资格列入。预计研究结果将于2024年底提交同行评审期刊发表。
结论:这项研究将提供最新的,关于生活方式干预对2型糖尿病高危个体绝对CVD风险和CVD风险因素影响的系统综合证据。
背景:PROSPEROCRD42023429869;https://tinyurl.com/59ajy7rw.
■DERR1-10.2196/53517。
BACKGROUND: Individuals at high risk for type 2 diabetes are also at an increased risk for developing cardiovascular disease (CVD). Although there are separate trials examining the effects of lifestyle interventions on absolute CVD risk among people at high risk for type 2 diabetes, a comprehensive evidence synthesis of these trials is lacking.
OBJECTIVE: We will systematically synthesize the evidence on the effects of lifestyle interventions in reducing absolute CVD risk and CVD risk factors among people at high risk for type 2 diabetes.
METHODS: We adhered to the PRISMA-P (Preferred Reporting Items for Systematic
Review and Meta-Analysis Protocols) statement in reporting the details of this protocol. Randomized controlled trials of diabetes prevention that examined the effects of lifestyle interventions for at least 6 months on absolute CVD risk and CVD risk factors among individuals at high risk for type 2 diabetes will be eligible. We will systematically search the MEDLINE, Embase, PsycINFO, CENTRAL, and Scopus databases and ClinicalTrials.gov using a mix of Medical Subject Headings and text words. Two authors will independently screen the abstract and title of the articles retrieved from the search, followed by full-text reviews using the inclusion and exclusion criteria and data extraction from the eligible studies. Article screening and data extraction will be performed in the Covidence software. The primary outcome will be the changes in absolute 10-year CVD risk, as estimated by risk prediction models. The secondary outcomes are the changes in CVD risk factors, including behavioral, clinical, biochemical, and psychosocial risk factors, and incidence of type 2 diabetes.
RESULTS: An initial database search was conducted in July 2023. After screening 1935 articles identified through the database search, 42 articles were considered eligible for inclusion. It is anticipated that the study findings will be submitted for publication in a peer-reviewed journal by the end of 2024.
CONCLUSIONS: This study will provide up-to-date, systematically synthesized evidence on the effects of lifestyle interventions on absolute CVD risk and CVD risk factors among individuals at high risk for type 2 diabetes.
BACKGROUND: PROSPERO CRD42023429869; https://tinyurl.com/59ajy7rw.
UNASSIGNED: DERR1-10.2196/53517.