背景:身体成分,血压,估计最大摄氧量(VO2max),肺功能,身体活动,肌肉结构,和内皮功能以前没有在年轻的痴呆患者中进行过检查。因此,这项研究测量了一个年轻的痴呆组的这些变量,将它们与年龄匹配的对照进行比较。
方法:估计VO2max(通过Astrand-Rhyming检验),身体成分,血压,肺功能(通过肺活量测定),评估了肌肉结构(通过超声检查)和内皮功能(通过血流介导的扩张).使用ActiGraph加速度计测量7天的身体活动。
结果:我们招募了33名参与者(16名年轻的痴呆症,17个控件)。年轻的痴呆组的股外侧肌的束长较短,在七天内久坐不动,并且完成了比对照组更少的中等强度体力活动(p=0.028,d=0.81;效果大,p=0.029,d=0.54;中等效果,p=0.014,d=0.97;效应大,分别用于成对比较)。配对比较表明,对于估计的VO2max,年轻发作性痴呆与对照组之间的p<0.05水平没有差异(尽管效应大小适中[d=0.66])。高度,体重,BMI,血压,轻微的身体活动,肺功能,肌肉厚度,悬念角度,或内皮功能。
结论:这项研究强调了年轻痴呆患者和对照组之间的差异,强调需要多成分运动干预。未来的干预措施应针对肌肉结构,增加中等强度的体力活动,减少镇静,以改善生活质量和促进功能独立为目标。
BACKGROUND: Body composition, blood pressure, estimated maximal oxygen uptake (VO2max), lung function, physical activity, muscle architecture, and endothelial function had not previously been examined in people with young onset dementia. Therefore, the study measured these variables in a young onset dementia group, compared them to age-matched controls.
METHODS: Estimated VO2max (via the Astrand-Rhyming test), body composition, blood pressure, lung function (via spirometry), muscle architecture (via ultrasonography) and endothelial function (via flow mediated dilation) were assessed. Physical activity was measured using ActiGraph accelerometers for 7 days.
RESULTS: We recruited 33 participants (16 young onset dementia, 17 controls). The young onset dementia group had shorter fascicle lengths of the vastus lateralis, were sedentary for longer over a seven-day period, and completed less moderate-vigorous physical activity than controls (p=0.028, d=0.81; large effect, p=0.029, d=0.54; moderate effect, and p=0.014, d=0.97; large effect, respectively for pairwise comparisons). Pairwise comparisons suggest no differences at the p<0.05 level between young onset dementia and controls for estimated VO2max (despite a moderate effect size [d=0.66]), height, body mass, BMI, blood pressure, light physical activity, lung function, muscle thickness, pennation angle, or endothelial function.
CONCLUSIONS: This study highlights differences between people with young onset dementia and controls, underscoring the need for multicomponent exercise interventions. Future interventions should target muscle architecture, increase moderate-vigorous physical activity, and reduce sedentariness, with the goal of improving quality of life and promoting functional independence.