■患有肺癌的年轻患者代表患有这种肿瘤的患者的不同子集。年轻的国际研究表明,女性肺癌发病率增加,而男性的发病率持续下降。有证据表明,这种趋势在年轻患者中复发。我们研究了性别差异对年轻人肺癌手术分期的发生率及其死亡率的影响。
■这项研究是对患有肺癌手术期的年轻成年人(年龄在45岁以下)的回顾性研究(2010-2020年)。我们计算了发病率比率的男女差异,肿瘤特征,手术管理,和生存。通过Kaplan-Meier方法产生累积存活曲线。
■我们检查了46名男性和24名女性,45岁以下。女性患者在早期阶段被诊断。女性IA期疾病的比例明显高于男性(46%对13%,分别)(p=0.03)。女性更有可能从不吸烟(42%对83%,p=0.02)。组织学亚型,女性更容易患典型类癌(13.54%与男性10.21%)(p>0.05)。男性中最大的组织学类型是腺癌(25.53%对4.16%,p>0.05)。所有患者均行手术治疗。三名男子接受了新辅助化疗,其中一名在胸部手术前接受了脑寡转移手术。给予7名女性和21名男性辅助化疗。尽管我们的研究中术后并发症的数量较少(n=8,11.2%),男性在预测该并发症方面具有重要意义(p<0.05)。死亡率为1.4%。男性的5年总生存率为84%,女性为87%。
■我们的研究确定了年轻人中外科肺癌发病率和死亡率的性别差异。但与这些差异有关的生物和内分泌机制尚未确定。
UNASSIGNED: Young Patients with lung cancer represent a distinct subset of patients with this neoplasm. Young International studies show increased lung cancer rates in females, while the incidence in males continues to decline. There is evidence to suggest that this trend recurs in younger patients. We studied the effects of gender differences on the incidence of surgical stages of lung cancer in young adults and its mortality rate.
UNASSIGNED: This study is a retrospective review (2010-2020) of young adults (aged under 45 years) with surgical-stage of lung cancer. We calculated female-to-male differences in incidence rate ratios, tumor characteristics, surgical management, and survival. Cumulative survival curves were generated by the Kaplan-Meier method.
UNASSIGNED: We examined 46 men and 24 women, under 45 years. Female patients were diagnosed at earlier stages. The proportion of stage IA disease was significantly higher in women than in men (46% versus 13%, respectively) (p=0.03). Women were more likely never smokers (42% versus 83%, p=0.02). A histologic subtype, females were more likely to have typical carcinoid tumors (13.54% versus 10.21% for males) (p>0.05). The largest histological type in men was adenocarcinoma (25.53% versus 4.16%, p>0.05). All the patients were operated. Three men had neoadjuvant chemotherapy and one was operated on for cerebral oligometastatic before his chest surgery. Adjuvant chemotherapy was given to 7 women and 21 men. Despite the small number of postoperative complications in our study (n= 8, 11.2%), the male sex was significant in predicting this complication (p<0.05). The mortality rate was 1.4%. The 5-year overall survival rates were 84% in men and 87% in women.
UNASSIGNED: Our study identified sex differences in the incidence and mortality rates for surgical lung cancers in young adults, but the biological and endocrine mechanisms implicated in these disparities have not yet been determined.