■我们的目标是描述全球育龄妇女(WCBA)中缺血性心脏病(IHD)的当前患病率和死亡情况。区域,和国家层面,并分析其1990年至2019年的时间趋势。
■WCBA定义为15-49岁女性。从2019年全球疾病负担研究中提取了七个年龄组的IHD患病率和死亡人数的估计值和95%的不确定性区间(UI)。使用直接年龄标准化方法估计WCBA中IHD的年龄标准化患病率和死亡率(ASPR和ASDR)。Joinpoint回归分析用于计算平均年变化百分比(AAPC),以代表1990年至2019年的时间趋势。
■在1990年至2019年之间,IHD的全球ASPR增长了3.21%,最终达到367.21(95%UI,295.74-430.16)每100,000个人的案例。相反,ASDR降至11.11(95%UI,10.10-12.30)每100,000个人。2019年,在五个社会人口指数(SDI)地区中,在中高SDI地区观察到最高的ASPR,而ASDR最高的是中低SDI地区。区域,加勒比海地区报告的ASPR最高(每10万人563.11;95%UI,493.13-643.03),大洋洲报告的ASDR最高(每100,000个人20.20;95%UI,13.01-31.03)。在国家一级,特立尼达和多巴哥的ASPR最高(每100,000个人730.15;95%UI,633.96-840.13),所罗门群岛的ASDR最高(每10万人中77.77人;95%UI,47.80-121.19)。重要的是,在过去的三十年里,全球ASPR显着增加[AAPC=0.11%,95%置信区间(CI):0.09-0.13;P<0.001],虽然ASDR呈显著下降趋势(AAPC=-0.86%,95%CI:-1.11至-0.61;P<0.001)。空气污染,烟草使用,高收缩压,身体质量指数升高,饮食风险,和高LDL胆固醇已被确定为2019年WCBA中IHD相关死亡的六个主要危险因素。
■尽管过去三十年来WCBA中IHD的全球ASDR显着下降,ASPR继续升级。我们需要对WCBAIHD负担的增加保持警惕。它要求采取积极的预防策略,严格控制风险因素,以及在未来几年中提高医疗保健覆盖率,以减轻WCBA中IHD的疾病负担。
UNASSIGNED: Our objective is to describe the current prevalence and death of ischemic heart disease (IHD) in women of childbearing age (WCBA) at the global, regional, and national levels and to analyze its temporal trends from 1990 to 2019.
UNASSIGNED: WCBA was defined as women aged 15-49 years. Estimates and 95% Uncertainty Intervals (UI) of IHD prevalence and death numbers for seven age groups were extracted from the 2019 Global Burden of Disease Study. The age-standardized prevalence and death rate (ASPR and ASDR) of IHD in WCBA was estimated using the direct age-standardization method. Joinpoint regression analysis was used to calculate average annual percent change (AAPC) to represent the temporal trends from 1990 to 2019.
UNASSIGNED: Between 1990 and 2019, the global ASPR of IHD experienced a 3.21% increase, culminating in 367.21 (95% UI, 295.74-430.16) cases per 100,000 individuals. Conversely, the ASDR decreased to 11.11 (95% UI, 10.10-12.30) per 100,000 individuals. In 2019, among the five sociodemographic index (SDI) regions, the highest ASPR was observed in the high-middle SDI region, whereas the highest ASDR was found in the low-middle SDI region. Regionally, the Caribbean reported the highest ASPR (563.11 per 100,000 individuals; 95% UI, 493.13-643.03), and Oceania reported the highest ASDR (20.20 per 100,000 individuals; 95% UI, 13.01-31.03). At the national level, Trinidad and Tobago exhibited the highest ASPR (730.15 per 100,000 individuals; 95% UI, 633.96-840.13), and the Solomon Islands had the highest ASDR (77.77 per 100,000 individuals; 95% UI, 47.80-121.19). Importantly, over the past three decades, the global ASPR has seen a significant increase [AAPC = 0.11%, 95% Confidence Interval (CI): 0.09-0.13; P < 0.001], while the ASDR has demonstrated a significant decreasing trend (AAPC = -0.86%, 95% CI: -1.11 to -0.61; P < 0.001). Air pollution, tobacco use, high systolic blood pressure, elevated body mass index, dietary risks, and high LDL cholesterol have been identified as the leading six risk factors for IHD-related deaths among WCBA in 2019.
UNASSIGNED: Despite the significant decline in the global ASDR for IHD among WCBA over the last thirty years, the ASPR continues to escalate. We need to remain vigilant about the increased burden of IHD in WCBA. It calls for aggressive prevention strategies, rigorous control of risk factors, and the enhancement of healthcare coverage to mitigate the disease burden of IHD among WCBA in forthcoming years.