■哮喘患者对特定空气过敏原的致敏与预后之间的关系已得到充分研究;然而,在普通儿科人群中,儿童期起病的喘息/哮喘与对各种空气过敏原和食物过敏原的致敏之间的关系仍然知之甚少.
■我们试图研究普通儿科人群中对常见空气过敏原和食物过敏原的致敏与喘息和2型(T2)炎症之间的关联。
■在428名学龄儿童(年龄~10岁)的前瞻性北海道出生队列中测量了针对9种空气过敏原和4种食物过敏原的特异性IgE。使用国际儿童期哮喘和过敏研究问卷评估喘息和其他过敏症状。血液嗜酸性粒细胞计数和部分呼出气一氧化氮水平被评估为T2生物标志物。英国的怀特岛出生队列用于复制分析(n=1032)。
■对至少一种空气过敏原和食物过敏原致敏的患病率分别为70.5%和22.3%,分别。喘息和对气敏原的致敏作用之间存在显著关联,如:日本雪松,艾草,发现了宠物皮屑.然而,喘息与小麦致敏之间的关联非常显着(北海道出生队列:优势比,4.67;95%CI,1.98-11.01;怀特岛出生队列,赔率比,4.01;95%CI,1.78-9.07)。对大多数空气过敏原致敏,虽然没有任何食物过敏原,与T2高表型相关。
■对小麦的敏感可能是喘息/哮喘发展的重要危险因素,特别是T2-非/低哮喘的发病机制,独立于空气过敏原,在普通儿科人群中。
UNASSIGNED: The association between sensitization to specific aeroallergens and outcomes in patients with asthma is well researched; however, the association between childhood-onset
wheeze/asthma and sensitization to various aeroallergens and food allergens in the general pediatric population remains poorly understood.
UNASSIGNED: We sought to investigate the association between sensitization to common aeroallergens and food allergens with
wheeze and type 2 (T2) inflammation in the general pediatric population.
UNASSIGNED: Specific IgEs against 9 aeroallergens and 4 food allergens were measured in the prospective Hokkaido birth cohort of 428 school-age children (age ∼10 years).
Wheeze and other allergic symptoms were assessed using the International Study of Asthma and Allergies in Childhood questionnaire. Blood eosinophil count and fractional exhaled nitric oxide level were assessed as T2 biomarkers. The Isle of Wight birth cohort in the United Kingdom was used for replication analysis (n = 1032).
UNASSIGNED: The prevalence of sensitization to at least 1 aeroallergen and food allergen was 70.5% and 22.3%, respectively. A significant association between
wheeze and sensitization to aeroallergens such as ragweed, Japanese cedar, mugwort, and pet dander was found. However, the association between
wheeze and wheat sensitization was highly significant (Hokkaido birth cohort: odds ratio, 4.67; 95% CI, 1.98-11.01; Isle of Wight birth cohort, odds ratio, 4.01; 95% CI, 1.78-9.07). Sensitization to most aeroallergens, though not any food allergen, was associated with the T2-high phenotype.
UNASSIGNED: Sensitization to wheat may be an important risk factor for wheeze/asthma development, especially the pathogenesis of T2-non/low asthma, independent of aeroallergens, in the general pediatric population.