■越来越多的研究已经检查了运动对多发性硬化症(MS)患者的影响,而现有研究的结果相互矛盾。这项荟萃分析旨在探讨运动对平衡的影响,行走能力,行走耐力,疲劳,和MS患者的生活质量
■我们搜索了PubMed,WebofScience,Scopus,和Cochrane数据库,到2024年3月1日纳入标准为:(1)随机对照试验;(2)包括干预组和对照组;(3)以MS患者为研究对象;(4)平衡,行走能力,行走耐力,疲劳,或生活质量作为结果指标。排除标准为:(1)非英文出版物;(2)动物模型出版物;(3)综述文章;和(4)会议文章。进行荟萃分析以计算加权平均差(WMD)和95%置信区间(CI)。使用Cochrane风险评估工具和物理治疗证据数据库(PEDro)量表评估纳入研究的方法学质量。
■共有56个运动组(n=1,300)和40个对照组(n=827)的40项研究符合荟萃分析的条件。锻炼显著改善了BBS(WMD,3.77;95%CI,3.01~4.53,P<0.00001),TUG(大规模杀伤性武器,-1.33;95%CI,-1.57至-1.08,P<0.00001),MSWS-12(大规模杀伤性武器,-2.57;95%CI,-3.99至-1.15,P=0.0004),6MWT(大规模杀伤性武器,25.56;95%CI,16.34至34.79,P<0.00001),疲劳(大规模杀伤性武器,-4.34;95%CI,-5.83至-2.84,P<0.00001),和MSQOL-54在MS患者中(WMD,11.80;95%CI,5.70至17.90,P=0.0002)亚组分析表明,有氧运动,阻力运动,和多组分训练都能有效改善MS患者的疲劳,阻力运动是最有效的干预类型。此外,年龄越小,疲劳改善越大.此外,有氧运动和多组分训练都能有效改善MS患者的生活质量,有氧运动是最有效的干预类型。
■运动对改善平衡有有益作用,行走能力,行走耐力,疲劳,和MS患者的生活质量抗阻运动和有氧运动是改善MS患者疲劳和生活质量的最有效干预措施,分别。运动对改善疲劳的效果与参与者的年龄有关,随着参与者的年龄越来越小,疲劳改善越大。
■https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=371056,标识符:CRD42022371056。
A growing body of studies have examined the effect of exercise in people with multiple sclerosis (MS), while findings of available studies were conflicting. This meta-analysis aimed to explore the effects of exercise on balance, walking ability, walking endurance, fatigue, and quality of life in people with MS.
We searched PubMed, Web of Science, Scopus, and Cochrane databases, through March 1, 2024. Inclusion criteria were: (1) RCTs; (2) included an intervention and control group; (3) had people with MS as study subjects; (4) had balance, walking ability, walking endurance, fatigue, or quality of life as the outcome measures. Exclusion criteria were: (1) non-English publications; (2) animal model publications; (3) review articles; and (4) conference articles. A meta-analysis was conducted to calculate weighted mean difference (WMD) and 95% confidence interval (CI). Cochrane risk assessment tool and Physiotherapy Evidence Database (PEDro) scale were used to evaluate the methodological quality of the included studies.
Forty studies with a total of 56 exercise groups (n = 1,300) and 40 control groups (n = 827) were eligible for meta-analysis. Exercise significantly improved BBS (WMD, 3.77; 95% CI, 3.01 to 4.53, P < 0.00001), TUG (WMD, -1.33; 95% CI, -1.57 to -1.08, P < 0.00001), MSWS-12 (WMD, -2.57; 95% CI, -3.99 to -1.15, P = 0.0004), 6MWT (WMD, 25.56; 95% CI, 16.34 to 34.79, P < 0.00001), fatigue (WMD, -4.34; 95% CI, -5.83 to -2.84, P < 0.00001), and MSQOL-54 in people with MS (WMD, 11.80; 95% CI, 5.70 to 17.90, P = 0.0002) in people with MS. Subgroup analyses showed that aerobic exercise, resistance exercise, and multicomponent training were all effective in improving fatigue in people with MS, with resistance exercise being the most effective intervention type. In addition, a younger age was associated with a larger improvement in fatigue. Furthermore, aerobic exercise and multicomponent training were all effective in improving quality of life in people with MS, with aerobic exercise being the most effective intervention type.
Exercise had beneficial effects in improving balance, walking ability, walking endurance, fatigue, and quality of life in people with MS. Resistance exercise and aerobic exercise are the most effective interventions for improving fatigue and quality of life in people with MS, respectively. The effect of exercise on improving fatigue was associated with the age of the participants, with the younger age of the participants, the greater the improvement in fatigue.
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=371056, identifier: CRD42022371056.