背景:据报道,在临床人群中,Ashwagandha可以减轻压力并减轻与炎症和神经变性相关的认知功能下降。然而,作为一种潜在的促智营养素对年轻人群的影响尚不清楚.这项研究检查了补充脂质体ashwagandha对认知功能的影响,心情,以及健康青年男女的健康和安全标志。
方法:59名男性和女性(22.7±7年。,74.9±16kg,26.2±5BMI)禁食12小时,捐献了一份空腹血液样本,并进行了COMPASS认知功能测试电池(WordRecall,单词识别,选择反应时间任务,图片识别,数字警戒任务,Corsi块试验,Stroop测试)和情绪状态简介(POMS)。以随机双盲的方式,参与者接受了225mg安慰剂(阿拉伯树胶)或涂有脂质体覆盖物的ashwagandha(Withaniasomnifera)根叶提取物.60分钟后,参与者重复认知评估。参与者继续补充(225mg/d)30天,然后返回实验室重复实验。使用一般线性模型(GLM)单变量分析对数据进行分析,重复测量,并以95%置信区间(CI)对基线的平均值变化进行配对比较。
结果:补充Ashwagandha改善了单词召回的急性和/或30天措施(正确和召回的尝试),选择反应时间(目标确定),图片识别(“是”正确回答,正确和整体的反应时间),数字警惕(正确的反应时间),Stroop颜色词(识别的全等词,反应时间),和POMS(紧张和疲劳)从基线更一致,组间观察到几个差异。
结论:结果支持以下观点:补充ashwagandha(225mg)可能会改善某些记忆力,注意,警惕,警惕注意,和执行功能,同时减少年轻健康个体对紧张和疲劳的看法。回顾性注册临床试验ISRCTN58680760。
BACKGROUND: Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation and neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient in younger populations are unclear. This study examined the effects of liposomal ashwagandha supplementation on cognitive function, mood, and markers of health and safety in healthy young men and women.
METHODS: 59 men and women (22.7 ± 7 yrs., 74.9 ± 16 kg, 26.2 ± 5 BMI) fasted for 12 h, donated a fasting blood sample, and were administered the COMPASS cognitive function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit
Vigilance Task, Corsi Block test, Stroop test) and profile of mood states (POMS). In a randomized and double-blind manner, participants were administered 225 mg of a placebo (Gum Arabic) or ashwagandha (Withania somnifera) root and leaf extract coated with a liposomal covering. After 60-min, participants repeated cognitive assessments. Participants continued supplementation (225 mg/d) for 30 days and then returned to the lab to repeat the experiment. Data were analyzed using a general linear model (GLM) univariate analysis with repeated measures and pairwise comparisons of mean changes from baseline with 95% confidence intervals (CI).
RESULTS: Ashwagandha supplementation improved acute and/or 30-day measures of Word Recall (correct and recalled attempts), Choice Reaction Time (targets identified), Picture Recognition (\"yes\" correct responses, correct and overall reaction time), Digit
Vigilance (correct reaction time), Stroop Color-Word (congruent words identified, reaction time), and POMS (tension and fatigue) from baseline more consistently with several differences observed between groups.
CONCLUSIONS: Results support contentions that ashwagandha supplementation (225 mg) may improve some measures of memory, attention,
vigilance, attention, and executive function while decreasing perceptions of tension and fatigue in younger healthy individuals. Retrospectively registered clinical trial ISRCTN58680760.