目的:霍乱是由霍乱弧菌(V.霍乱)。阻止细胞壁合成的抗生素是第一个已知的抗生素组。由于它的高消费,V.霍乱已对该类中的大多数抗生素产生耐药性。对推荐用于治疗霍乱弧菌的抗生素的抗性也增加。鉴于该组中某些抑制细胞壁合成的抗生素的消费减少和新抗生素的实施,有必要确定霍乱弧菌的抗生素耐药模式,并采用最有效的治疗抗生素。方法:在PubMed上对相关文章进行全面系统的检索,WebofScience,Scopus,和EMBASE到2020年10月。Stata版本17.1使用Metaprop包执行Freeman-Tukey双反正弦变换,以估计加权合并比例。结果:共有131篇文献被纳入荟萃分析。氨苄西林是研究最多的抗生素。抗生素耐药性的患病率依次为氨曲南(0%),头孢吡肟(0%),亚胺培南(0%),美罗培南(3%),磷霉素(4%),头孢他啶(5%),头孢菌素(7%),Augmentin(8%),头孢氨苄(8%),头孢曲松(9%),头孢呋辛(9%),头孢噻肟(15%),头孢克肟(37%),阿莫西林(42%),青霉素(44%),氨苄青霉素(48%),头孢西丁(50%),cefamandole(56%),多粘菌素B(77%),羧苄青霉素(95%)。讨论:氨曲南,头孢吡肟,和亚胺培南是最有效的霍乱弧菌细胞壁合成抑制剂。对头孢菌素等抗生素的耐药性有所增加,头孢曲松,阿莫西林,还有美罗培南.多年来,对青霉素的抗药性,头孢他啶,和头孢噻肟,减少了。
Objective: Cholera is a challenging ancient disease caused by Vibrio cholera (V. cholera). Antibiotics that prevent cell wall synthesis are among the first known antibiotic groups. Due to its high consumption, V. cholera has developed resistance to the majority of antibiotics in this class. Resistance to recommended antibiotics for the treatment of V. cholera has also increased. In light of the decrease in consumption of certain antibiotics in this group that inhibit cell wall synthesis and the implementation of new antibiotics, it is necessary to determine the antibiotic resistance pattern of V. cholera and to employ the most effective treatment antibiotic. Method: An comprehensive systematic search for relevant articles was conducted in PubMed, Web of Science, Scopus, and EMBASE through October 2020. Stata version 17.1 utilized the Metaprop package to execute a Freeman-Tukey double arcsine transformation in order to estimate weighted pooled proportions. Results: A total of 131 articles were included in the meta-analysis. Ampicillin was the most investigated antibiotic. The prevalence of antibiotic resistance was in order aztreonam (0%), cefepime (0%), imipenem (0%), meropenem (3%), fosfomycin (4%), ceftazidime (5%), cephalothin (7%), augmentin (8%), cefalexin (8%), ceftriaxone (9%), cefuroxime (9%), cefotaxime (15%), cefixime (37%), amoxicillin (42%), penicillin (44%), ampicillin (48%), cefoxitin (50%), cefamandole (56%), polymyxin-B (77%), carbenicillin (95%) respectively. Discussion: Aztreonam, cefepime, and imipenem are the most efficient V. cholera cell wall synthesis inhibitors. There has been an increase in resistance to antibiotics such as cephalothin, ceftriaxone, amoxicillin, and meropenem. Over the years, resistance to penicillin, ceftazidime, and cefotaxime, has decreased.