■右心室(RV)具有复杂的几何形状和功能,沿着三个独立的纵向轴运动,径向,和前后。由于这种复杂性,通过二维超声心动图(2DE)对RV功能的定量评估受到限制。而较新的三维(3D)分析提供了对RV功能的贡献者进行更全面评估的潜力。这项研究的目的是量化纵向,在一组健康儿童中,使用3D超声心动图检查整体RV功能的径向和前后分量,并检查这些参数的成熟变化。
■RV的三维轮廓是从两个中心具有结构正常心脏的健康儿科患者队列中生成的。记录传统的2D和3D回波特性。使用3D数据集的离线分析,RV运动被分解为三个组成部分,计算射血分数(EF)(纵向LEF;径向REF和前后AEF)。将各个分解的EF值相对于全局RVEF进行索引。还计算了应变值。
■来自166名受试者的数据被纳入分析;中位年龄为13.5岁(范围为0至17.4岁)。总的来说,AEF大于REF和LEF(29.2±6.2%vs.25.1±7.2%和25.7±6.0%,分别为;p<0.001)。按总EF指数计算时仍然如此(49.8±8.7%与43.3±11.6%和44.4±10%,分别为;p<0.001)。全球RVEF存在与年龄相关的差异,REF,和RV菌株的所有成分。
■在健康儿童中,前后缩短是RV收缩的主要组成部分。评价儿童RV的三维参数是可行的,增强了对RV功能的整体认识,这可能会改善对功能障碍的识别和未来治疗效果的评估。
UNASSIGNED: The right ventricle (RV) has complex geometry and function, with motion along three separate axes-longitudinal, radial, and anteroposterior. Quantitative assessment of RV function by two-dimension echocardiography (2DE) has been limited as a consequence of this complexity, whereas newer three dimensional (3D) analysis offers the potential for more comprehensive assessment of the contributors to RV function. The aims of this study were to quantify the longitudinal, radial and anteroposterior components of global RV function using 3D echocardiography in a cohort of healthy children and to examine maturational changes in these parameters.
UNASSIGNED: Three-dimensional contours of the RV were generated from a cohort of healthy pediatric patients with structurally normal hearts at two centers. Traditional 2D and 3D echo characteristics were recorded. Using offline analysis of 3D datasets, RV motion was decomposed into three components, and ejection fractions (EF) were calculated (longitudinal-LEF; radial-REF; and anteroposterior-AEF). The individual decomposed EF values were indexed against the global RVEF. Strain values were calculated as well.
UNASSIGNED: Data from 166 subjects were included in the analysis; median age was 13.5 years (range 0 to 17.4 years). Overall, AEF was greater than REF and LEF (29.2 ± 6.2% vs. 25.1 ± 7.2% and 25.7 ± 6.0%, respectively; p < 0.001). This remained true when indexed to overall EF (49.8 ± 8.7% vs. 43.3 ± 11.6% and 44.4 ± 10%, respectively; p < 0.001). Age-related differences were present for global RVEF, REF, and all components of RV strain.
UNASSIGNED: In healthy children, anteroposterior shortening is the dominant component of RV contraction. Evaluation of 3D parameters of the RV in children is feasible and enhances the overall understanding of RV function, which may allow improvements in recognition of dysfunction and assessment of treatment effects in the future.