目的是阐明自1980年以来加蓬疟疾流行病学的时空变化。为此,五个数据库,用于收集和鉴定1980年至2023年之间发表的关于疟疾流行的所有研究,抗疟药耐药性,抗疟药抗性标记和杀虫剂抗性标记。研究结果表明,加蓬继续将疟疾作为一个紧迫的公共卫生问题,患病率持续较高。尽管CQ退出,但抵制CQ的标志仍然存在,并且对SP的抗性标记以很高的频率出现,达到100%,而ACTs仍然有效。此外,最近的研究已经确定了对杀虫剂Kdr-w和Kdr-e的抗性标记,频率范围为25%至100%。据报道,Ace1R突变的频率为0.4%。总之,ACTs的疗效仍高于WHO建议的阈值.有机磷酸盐和氨基甲酸酯可以为病媒控制提供替代方案。
The objective of this were conducted to elucidate spatiotemporal variations in malaria epidemiology in Gabon since 1980. For that, five databases, were used to collect and identify all studies published between 1980 and 2023 on malaria prevalence, antimalarial drug resistance, markers of antimalarial drug resistance and insecticide resistance marker. The findings suggest that Gabon continues to face malaria as an urgent public health problem, with persistently high prevalence rates. Markers of resistance to CQ persist despite its withdrawal, and markers of resistance to SP have emerged with a high frequency, reaching 100 %, while ACTs remain effective. Also, recent studies have identified markers of resistance to the insecticides Kdr-w and Kdr-e at frequencies ranging from 25 % to 100 %. Ace1R mutation was reported with a frequency of 0.4 %. In conclusion, the efficacy of ACTs remains above the threshold recommended by the WHO. Organo-phosphates and carbamates could provide an alternative for vector control.