■在过去的37年中,文献中仅报道了27例马结膜血管肉瘤。在这些中,22%的病例失访,52%被安乐死,26%幸存下来。对于这种罕见的结膜肿瘤,缺乏病例和信息。
■为了描述临床特征,管理,以及英国7匹马结膜血管肉瘤的结局。
■在2013年1月至2023年3月期间,对观察到或建议接受组织病理学诊断为结膜血管肉瘤的马病例进行了审查。查看了医疗记录以了解信号的详细信息,历史,管理,和后续行动。组织病理学用于确认血管肉瘤的诊断并评估手术切缘。在少数低分化实体瘤病例中进行了免疫组织化学,以支持血管谱系。
■来自七匹马(五匹凝胶和两匹母马)的七只眼睛,平均年龄为16岁,中位数为18岁(范围为10-21岁)符合标准。在六只眼睛中看到了蛇毒放电。所有眼睛均通过手术进行处理;4例通过切除术,3例通过结膜切除术/角膜切除术。在两只眼睛中进行辅助冷冻治疗。患侧腮腺的转移性疾病,经组织病理学证实,看到一匹马。除一只眼睛外,所有手术边缘均清晰。在五只眼睛中发现了日光弹性沉着症。所有马匹在最后一次随访时都是健康的(0.2-5年,平均2.9年,和中位数2年)。
■马结膜血管肉瘤是罕见的。血汗膜眼放电是一种常见的临床体征。早期手术切除非常有效。日光弹性沉着症是一种常见的组织病理学特征,提示紫外线在发病机理中的作用。
UNASSIGNED: Only 27 cases of equine conjunctival haemangiosarcoma have been reported in the literature over the past 37 years. Out of these, 22% of cases were lost to follow-up, 52% were euthanized, and 26% survived. A scarcity of cases and information is available for this rarely seen conjunctival tumour.
UNASSIGNED: To describe the clinical features, management, and outcome of conjunctival hemangiosarcoma in seven horses in the UK.
UNASSIGNED: Optivet medical records were reviewed for equine cases seen or advised on with a histopathological diagnosis of conjunctival haemangiosarcoma between January 2013 and March 2023. Medical records were accessed for details of signalment, history, management, and follow-up. Histopathology was used to confirm the diagnosis of haemangiosarcoma and assess the surgical margins. Immunohistochemistry was performed in a minority of cases with poorly differentiated solid tumours to support vascular lineage.
UNASSIGNED: Seven eyes from seven horses (five geldings and two mares) with a mean age of 16 years and median of 18 years (range 10-21 years) met the criteria. Serosanguinous discharge was seen in six eyes. All eyes were managed surgically; 4 by exenteration and 3 by conjunctivectomy/keratectomy. Adjunctive cryotherapy was performed in two eyes. Metastatic disease in the ipsilateral parotid salivary gland, confirmed with histopathology, was seen in one horse. Surgical margins were clear in all but one eye. Solar elastosis was noted in five eyes. All horses were healthy at the last follow-up (0.2-5 years, mean 2.9 years, and median 2 years).
UNASSIGNED: Equine conjunctival haemangiosarcoma is rare. Serosanguinous ocular discharge is a common clinical sign. Early surgical excision is highly effective. Solar elastosis is a common histopathological feature, suggesting a role for UV-light in the pathogenesis.