背景:海绵状瘤是具有遗传遗传的血管病变,可以在中枢神经系统上发现。每当这些病变位于雄辩的区域时,不建议手术切除。在这种情况下,伽玛刀立体定向放射外科(GKRS)可能是治疗患者的可行选择。因此,我们旨在探讨与该手术相关的结局.
方法:我们基于Kaplan-Meier曲线对重建的事件发生时间数据进行了系统回顾和荟萃分析。在PubMed上进行了彻底的搜索,科克伦,WebofScience和Embase数据库针对通过Kaplan-Meier曲线提供与GKRS相关的出血结果信息的论文。
结果:在特定数据库中进行系统搜索后,本综述纳入了7项研究.值得注意的是,共有1071例患者有1104例接受GKRS治疗的海绵体瘤.对手术后的短期和长期结果进行评估,估计2年的总体无事件率为89.8%(95%CI87.7-91.5),while,十年后,估计的总体无事件率为71.3%(95%CI67.2~75.1).
结论:在早期和长期随访中,GKRS似乎是控制症状事件的良好选择。尽管未来的研究需要进一步的调查。
BACKGROUND: Cavernomas are vascular lesions with a genetic heritage that can be spotted on the central nervous system. Whenever these lesions are localized in eloquent regions, surgical resection is not recommended. In this type of situation, Gamma Knife stereotactic radiosurgery (GKSRS) could be a feasible option for treating patients. Thus, we aimed to explore the outcomes associated with this procedure.
METHODS: We performed a systematic review and meta-analysis of reconstructed time-to-event data based on Kaplan-Meier curves. A thorough search was conducted on PubMed, Cochrane, Web of Science, and Embase databases targeting papers that provided information regarding hemorrhagic outcomes associated with GKSRS through Kaplan-Meier curves.
RESULTS: After a systematic search in the specific databases, seven studies were included in this review. Notably, a total of 1,071 patients had 1,104 cavernomas treated by GKSRS. Assessment of short-term and long-term post-procedure outcomes was performed, with the estimated overall events-free rate at 2 years being 89.8% (95% CI: 87.7-91.5), while, at 10 years, the estimated overall events-free rate was 71.3% (95% CI: 67.2-75.1).
CONCLUSIONS: GKSRS seems to be a good alternative for the control of symptomatic events in early and long-term follow-up, despite the need for further investigation provided by future studies.